search

obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
Other
286 stars 51 forks source link

NTR: Anticholinergic drug toxicity (Triggers or responses: drugs or treatments) #9513

Closed pnrobinson closed 1 year ago

pnrobinson commented 1 year ago

New term request Anticholinergic drug toxicity (segal_211028185209): Atropine, benztropine, scopolamine, diphenhydramine, antihistamines, jimson weed, nightshade, phenothiazines, tricyclics UMLS: 0416669

pnrobinson commented 1 year ago

@MickeySegal

I do not think the "X drug toxicity" items are good HPO terms because they can include multiple phenotypic features and also include etiology. Possibly terms from the OAE are better suited, e.g., : https://www.ebi.ac.uk/ols4/ontologies/oae/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FOAE_0005827

thoughts?

MickeySegal commented 1 year ago

"Cholinergic syndrome" would be fine, but as someone who did a PhD thesis on cholinergic receptors, it doesn't seem much different.

pnrobinson commented 1 year ago

I mean the issue is that if we start to introduce terms such as X toxicity for side effects caused by medication X, we will need to add terms for all medications and this is probably not the way to go?

MickeySegal commented 1 year ago

It is meant to be the finding for the diagnosis "Anticholinergic intoxication".

pnrobinson commented 1 year ago

In the HPO universe, these "intoxication" items would probably be best described as (acute) diseases -- they have a specific etiology, they have a collection of phenotypic features (here: delirium, restlessness and picking at imaginary objects), a typical clinical course and a treatment. So these would be good Mondo terms. @nicolevasilevsky I am closing the HPO NTRs, and we can think about whether to add a "toxidrome" branch to Mondo.