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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR: Opioid drug toxicity (Triggers or responses: drugs or treatments) #9516

Closed pnrobinson closed 9 months ago

pnrobinson commented 1 year ago

New term request Opioid drug toxicity (segal_211028200150): Heroin, morphine, fentanyl, oxycodone; opiates UMLS: 0029100

pnrobinson commented 1 year ago

@MickeySegal I am not sure that the "toxixity" term requests are actually phenotypic features (observations) rather than inferences about side effects? Can we discuss this issue?

MickeySegal commented 1 year ago

You are right. I changed it to "use or abuse". We use the finding for a variety of diagnoses such as "Opioid withdrawal syndrome" and "Ileus".

pnrobinson commented 1 year ago

@MickeySegal Is it then this Opioid addiction HP:0033515

pnrobinson commented 1 year ago

@MickeySegal similar questions about #9515 #9514 #9513 #9512 -- should these be "Triggered by X" ?

MickeySegal commented 1 year ago

I imagine the following ontology: Parent term : taking opioids

The diagnoses for which we use our term are opioid toxicity, opioid withdrawal, and ileus. In all 3, it doesn't really matter whether you have a good or bad reason for taking opioids, hence the desire for the parent term or the 2 child terms.

Triggered might be OK for the parent term, but I think of trigger as more appropriate for something like hyperventilation triggering absence seizures. Here, the triggering is less obvious. The way we use these findings is that they are suggested as being useful diagnostically. Here the question I'd want to ask is "Are you on opioids?" not "Was this triggered by opioids?" or "Are you an opioid abuser?"

I reviewed the other terms as well, and it seems that a title along the lines of "Taking X" would be the best choice.

pnrobinson commented 9 months ago

@MickeySegal see https://github.com/obophenotype/human-phenotype-ontology/issues/9512