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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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Pagetoid Proliferation #9951

Open MickeySegal opened 1 year ago

MickeySegal commented 1 year ago

Preferred term label: Pagetoid Proliferation

Synonyms Skip lesions, non-cohesive spread, spotty spread, eyelid/conjunctival involvement, intraepidermal spread

Definition (free text, please give PubMed ID) https://www.ncbi.nlm.nih.gov/medgen/C1335292

Parent term (use hpo.jax.org/app)

Diseases characterized by this term ? (e.g. Orphanet or OMIM number) Sebaceous cell carcinoma of the eyelid

Your nano-attribution (ORCID)

pnrobinson commented 6 months ago

@MickeySegal I think it is probably better to make a term "Sebaceous Carcinoma of the Eyelid", because the above is one of the findings of that disease?

https://pubmed.ncbi.nlm.nih.gov/33347004/

MickeySegal commented 6 months ago

The point of having a clinical finding is that it can be observed by a clinician without doing a lab test. substituting a pathological diagnosis loses the value of that clinical observation. https://eyewiki.org/Sebaceous_Carcinoma "One of the hallmark features of sebaceous carcinoma is pagetoid spread--spreading of malignant cells to epithelium that appears to be separate from main tumor. "

pnrobinson commented 3 months ago

@MickeySegal yes but spreading of "malignant" cells means it is a lab test? I am not sure what the actual phenotypic observation is?

MickeySegal commented 3 months ago

The middle of the first set of 3 images shows the meaning macroscopically - I would call it skip lesions, but apparently Pagetoid spread is the term used by ophthalmologists.