proneural cluster

[cmungall]

We get a same-label-clash when trying to build uberon using the insect module. This comes from there being two classes called 'proneural cluster', one in the phenoscape-ext vertebrate extension module, the other in the insect module:

[Term]
id: UBERON:2000068
name: proneural cluster
namespace: uberon/phenoscape-anatomy
synonym: "proneural clusters" EXACT PLURAL [TAO:0000068]
xref: ZFA:0000068
is_a: UBERON:0002050  ! embryonic structure
is_a: UBERON:0004121  ! ectoderm-derived structure
relationship: part_of UBERON:0003075 ! neural plate
property_value: provenance_notes "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string

See the notes: this is an example of a class that was 'blindly abstracted' from ZFA. It lacks a text definition (because it was 'inherited' from TAO, which was made from an old ZFA), but we can see the intent from the current ZFA def:

def: "Cluster of cells in the neural plate that have the potential to become neuroblast." [ZFIN:ZDB-PUB-990921-1]

compare with the uberon-insect term:

[Term]
id: UBERON:6001135
name: proneural cluster
def: "An equivalence group of the neurectoderm where all cells can, although only one will, become a neural progenitor cell." [FlyBase:FBrf0074477, FlyBase:FBrf0089570]
xref: FBbt:00001135
is_a: UBERON:0007688 
relationship: only_in_taxon NCBITaxon:50557

similarly blindly abstracted from FBbt (as it was a descendant of a GO-referenced class)

There are obvious similarities in these terms, and there is an argument for having some kind of abstraction. But for now, they are two classes and the label clash is blocking the release. I will therefore relabel the vertebrate one for now to be 'neural plate proneural cluster'

[cmungall]

cc @wdahdul

[wdahdul]

Yes, I agree with the need to relabel the ext term. Thanks.

[dosumis]

General class looks justified. Both are clusters of cells that have the potential to become committed to a neuroblast fate. Looks like major differentium is the tissue in which this occurs - although I think both could be referred to as neurectoderm (https://en.wikipedia.org/wiki/Neuroectoderm)