cerebellum subterms

[cmungall]

cerebellum gross morphology

Original comment by: cindyJax

Original Ticket: obo/mouse-anatomy-requests/18

[cmungall]

cerebellum gross morphology

Original comment by: cindyJax

[cmungall]

This request is to add some new subterms to cerebellum and to reorganize/rename some existing terms.

First, please add cerebellum posterior lobe to complement cerebellum anterior lobe [ MA:0000991]; these should be a child of cerebellar cortex [MA:0000199] (generally considered to be regions of cerebellum that is anterior or posterior to the primary fissure) . Please also consider adding flocculonodular lobe (the small region of the cerebellum that is posterior to the posteriolateral fissure)

Then, add cerebellum lobule morphology with children cerebellum hemisphere lobule (child of cerebellum lobule and cerebellum hemisphere) and cerebellum vermis lobule (child of cerebellum lobule and cerebellum vermis) . The current cerebellum lobule I-X terms under cerebellum vermis should be renamed cerebellum vermis lobule I-X and placed under cerebellum vermis lobule.

Please also consider added anterior and posterior cerebellum vermis terms (children of anterior and posterior cerebellum, respectively as well as cerebellum vermis.

The cerebellum vermis lobules I-V can then be placed under cerebellum anterior vermis and cerebellum vermis lobules Vi-X (?) can be placed under posterior vermis.

I'm still working on the hemispheric lobule names and numbers.

I've attached a document summarized from NeuroLex about the location of the lobules, but it is human-centric.

Original comment by: cindyJax

[cmungall]

• priority: 1 --> 5

Original comment by: cindyJax

[cmungall]

cerebellar lobules and organization

Original comment by: cindyJax

[cmungall]

Some references: Apps R, Hawkes R. Cerebellar cortical organization: a one-map hypothesis. Nat Rev Neurosci. 2009 Sep;10(9):670-81. Review. PubMed PMID: 19693030. (figure of cerebellum gross anatomy is from this reference)

Sillitoe RV, Joyner AL. Morphology, molecular codes, and circuitry produce the three-dimensional complexity of the cerebellum. Annu Rev Cell Dev Biol. 2007;23:549-77. Review. PubMed PMID: 17506688.

Sudarov A, Joyner AL. Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers. Neural Dev. 2007 Dec 3;2:26. PubMed PMID: 18053187; PubMed Central PMCID: PMC2246128.

Original comment by: cindyJax

[cmungall]

Another useful reference:

Cooper PA, Benno RH, Hahn ME, Hewitt JK. Genetic analysis of cerebellar foliation patterns in mice (Mus musculus). Behav Genet. 1991 Jul;21(4):405-19. PubMed PMID: 1953602.

Original comment by: cindyJax

[cmungall]

This reference appears to describe the morphology of the hemispheres. I'll let you know if/when I get my hands on a full copy.

Acta Morphol Neerl Scand. 1979 Feb;17(1):33-52. The morphology of the mouse cerebellum.

Marani E, Voogd J.

In this description of the morphology of the mouse cerebellum, the main landmarks for subdivision were the discontinuities of the cortical sheet. In certain cerebellar sulci in the posterior lobe, the cortex is absent. Within the paramedian sulcus the cortex is interrupted rostral and caudal to the copula pyramidis. Rostrally, this discontinuity between vermis and hemisphere occupies a position corresponding to the intercrural sulcus of the ansiform lobule of other mammals. A subdivision into the simple lobule (VI and HVI), ansiform and paramedian lobule (HVII) and vermal lobule VII is proposed for this region, which accounts for the position of this cortexless area in the intercrural sulcus. Caudal to the copula pyramidis is the cortex is interrupted at the bottom of the paramedian sulcus between lobules X, IX and caudal VIII medially, and the paraflocculus and flocculus laterally. In most mammals, this area, devoid of cortex, extends much farther in the interparafloccular sulcus between the dorsal paraflocculus and the flocculus with the ventral paraflocculus. From the medullary surface of the cerebellar peduncles an area without cortex extends in between the ansiform lobule and the paraflocculus onto the copula pyramidis and the paramedian lobule. The nomenclature of the distal, foliated part of the paraflocculus in mouse, rat and rabbit is discussed.

PMID: 452954 [PubMed - indexed for MEDLINE]

Original comment by: cindyJax

[cmungall]

Created new term cerebellum lobe (MA:0002963) as part-of cerebellar cortex (MA:0000199), and moved existing term cerebellum 
anterior lobe [MA:0000991] to is-a cerebellum lobe. Then, created new term cerebellum posterior lobe (MA:0002964), also as is-a cerebellum lobe. Also created new term cerebellum flocculonodular lobe (MA:0002965) as is-a cerebellum lobe.

Created new terms cerebellum lobule (MA:0002966) as part-of cerebellar cortex, cerebellum hemisphere lobule (MA:0002967) as is-a cerebellum lobule and also as part-of cerebellum hemisphere (MA:0000200), and cerebellum vermis lobule (MA:0002968) as is-a cerebellum lobule and also as part-of cerebellum 
vermis (MA:0000202).

Renamed existing terms for cerebellum lobule I to X as cerebellum vermis lobule I-X and moved to is-a (MA:0000998 to MA:0001007) cerebellum 
vermis lobule.



Created anterior cerebellum vermis (MA:0002969), part-of cerebellum anterior lobe, and posterior cerebellum vermis (MA:
0002970), part of cerebellum posterior lobe, both also as part-of
 cerebellum vermis.



Then added cerebellum vermis lobules I-V as part-of cerebellum 
anterior vermis and cerebellum vermis lobules VI to VIII as part of cerebellum posterior vermis.

 (Based on the NeuroLex chart, wasn’t sure about IX and X, so left them out for now.)

Original comment by: tfhayamizu

[cmungall]

revised cerebellar cortex tree

Original comment by: tfhayamizu

[cmungall]

See attached pdf of revised tree. Please let me know if you notice anything incosistent or incorrect.

Original comment by: tfhayamizu

[cmungall]

• status: open --> open-accepted

Original comment by: tfhayamizu

[cmungall]

I think the revised tree looks great. I'm waiting on an ILL for a reference describing the hemisphere lobules in mouse and I'll enter another tracking record for those subterms when I get it.

Original comment by: cindyJax

[cmungall]

• status: open-accepted --> closed-accepted

Original comment by: tfhayamizu