NTR: brain germinal matrix

[jahilton]

The ENCODE DCC would like a term created for 'brain germinal matrix'

'The germinal matrix consists of a layer of cells near the fluid-containing ventricles of the brain. It is a highly cellular and highly vascularized region from which cells migrate out during brain development, mainly between 22 and 30 weeks gestation.'

part_of: UBERON:0000955 [brain] has_part CL:0000134 [mesenchymal stem cell]

http://www.ajnr.org/content/18/2/219.full.pdf http://library.med.utah.edu/WebPath/PEDHTML/PED058.html http://www.wisegeek.com/what-is-the-germinal-matrix.htm

[cmungall]

See also https://en.wikipedia.org/wiki/Germinal_matrix

OK, definitely need help from neurodevelopment experts here

here is a subset of relevant terms in the ontology (note I'm omitting multiple edges to make a simpler display, if an edge is not present here it does not mean it's missing in the ontology):

I show the adult neuroproliferative areas for comparison.

• UBERON:0003053 ! ventricular zone [DEF: "Proliferative region that is part of the ventricular system."]
• UBERON:0004023 ! ganglionic eminence [DEF: "The transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles[MP]."]
• UBERON:0010404 ! lateral ventricle subependymal layer [DEF: "A cell layer below the ependyma in the lateral ventricles of the brain. This region contains adult neural stem cells which have the potential to generate new neurons and glial cells via neurogenesis. It is an adult version of the embryonic forebrain germinal zone"]
• UBERON:0004922 ! postnatal subventricular zone [DEF: "A mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells[MP]."]
• UBERON:0004670 ! ependyma [DEF: "The thin epithelium-like membrane composed of ependymal cells that lines the ventricular system of the brain and the spinal cord."]
• UBERON:0004922 ! postnatal subventricular zone [DEF: "A mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells[MP]."]
• UBERON:0004060 ! neural tube ventricular layer [DEF: "The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium"]
• UBERON:0004022 ! germinal neuroepithelium [DEF: "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells"]

I think ganglionic eminence is too late and germinal neuroepithelium is too early

This part of the ontology needs attention!

[gouttegd]

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