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obophenotype / uberon

An ontology of gross anatomy covering metazoa. Works in concert with https://github.com/obophenotype/cell-ontology
http://obophenotype.github.io/uberon/
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NTR: parathyroid adenoma #1276

Closed jahilton closed 7 years ago

jahilton commented 7 years ago

The ENCODE DCC is requesting a term for 'parathyroid adenoma'

"Benign tumor located on a parathyroid gland, generally causing hyperparathyroidism through increased secretion of parathyroid hormone."

is_a: UBERON:0000479 ! tissue located_in: UBERON:0001132 ! parathyroid gland

http://jjco.oxfordjournals.org/content/34/3/155.full http://my.clevelandclinic.org/health/diseases_conditions/parathyroid-disease/hic_Parathyroid_adenoma_Diagnosis_and_treatment

cmungall commented 7 years ago

This of out of scope for uberon, consider NCIT or DO

jahilton commented 7 years ago

Could you explain a little further so that I can adjust future submissions? I see that mole is in UBERON [UBERON:1000010], so I had considered that precedent for tumors.

mellybelly commented 7 years ago

already in NCIT

Preferred Name: Parathyroid Gland Adenoma

Definition: A benign tumor arising from the parenchymal cells of the parathyroid glands. In the vast majority of cases, the tumor involves a single parathyroid gland. It is associated with the symptoms of primary hyperparathyroidism, resulting from the excessive production of parathyroid hormone. It is usually surrounded by a well-defined capsule. Capsular invasion, vascular invasion, and perineural invasion are absent.

Label: Parathyroid Gland Adenoma

NCI Thesaurus Code: C3916

On Oct 4, 2016, at 2:55 PM, Chris Mungall notifications@github.com<mailto:notifications@github.com> wrote:

This of out of scope for uberon, consider NCIT or DO

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Melissa Haendel, PhD Associate Professor Library & Dept. of Medical Informatics and Clinical Epidemiology haendel@ohsu.edumailto:haendel@ohsu.edu 503-407-5970 www.monarchinitiative.orghttp://www.monarchinitiative.org

Appointments: Shanez De Silva desilva@ohsu.edumailto:desilva@ohsu.edu

cmungall commented 7 years ago

see that mole is in UBERON [UBERON:1000010], so I had considered that precedent for tumors.

Well spotted! Yes, mole is kind of on the edge of acceptability. ZFA also has nevus. We could be persuaded to obsolete this but for now it's one of a handful of edge cases. Others include ascitic fluid. GO also has some potentially pathological entities like inclusion bodies.