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obophenotype / uberon

An ontology of gross anatomy covering metazoa. Works in concert with https://github.com/obophenotype/cell-ontology
http://obophenotype.github.io/uberon/
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Midzonal region of liver lobule #1649

Closed rich-brennan closed 3 years ago

rich-brennan commented 3 years ago

Preferred term label: Midzonal region

Synonyms Liver acinus zone 2

Definition (free text, please give PubMed ID) The hepatocellular cords are mostly one or two layers thick and are divided into three zones: 1, 2, and 3 of the acinus, and periportal (PP), mid‐ (MZ), and centrilobular (CL) zones of the lobule. Blood flows from the portal tract (PT) to the central vein, also referred to as terminal hepatic venule (CV/THV) (PMID: 30992875)

Parent term (use https://www.ebi.ac.uk/ols/ontologies/uberon) Liver Lobule (UBERON:0004647)

Your nano-attribution (ORCID) 0000-0002-0449-2730

rich-brennan commented 3 years ago

The differential sensitivity of cells in these zones to chemical injury means that the inclusion of the zone(s) affected is an important component of liver histopathology diagnoses. The NCIT ontology includes liver acinus zones as daughter terms of Digestive System Part (NCIT:C25763) – Liver Acinus Zone I (NCIT:C32993); Liver Acinus Zone 2 (NCIT:C32994); Liver Acinus Zone 3 (NCIT:C32995). Suggest adding lobule regions as daughter terms of Liver Lobule (UBERON:0004647). The preferred terminology for Toxicological Pathology would be: a. “Periportal Region” (equivalent to Zone 1) b. “Midzonal Region” (Zone 2) c. “Centrilobular Region” (Zone 3) *Note: technically acinus zones and lobule regions are not exactly the same since acinus zones are defined by functional differences whereas periportal, centrilobular, and midzonal regions are defined anatomically, however they are practically equivalent and the Wikipedia page for liver lobules conflates them.

mkeays commented 3 years ago

Added in #1648