The Human placenta in Uberon

[aleixpuigb]

The current representation of placenta in Uberon, does not reflect the human anatomy. The following edits have been proposed/requested to make the placenta Human aligned. The major points are:

• [ ] Placental arteries: Add new vascular terms under placental artery UBERON:8480007 and placental vein UBERON:8480008

  
  • Villous capillary as a child term of placenta blood vessel, instead of placental artery.

• [ ] Placental membrane: The term “placental membrane” in Uberon is not used in the way it is typically used in clinical pathology and obstetrics.

  • Proposal to utilize “placental membrane” in the “structural”/histopathologic term. Then “fetal membrane” should stay where it is (“fetal membrane” should still be made a synonym).

• [ ] Amnion and chorion: “Amnion” and “Chorion” are not related to the “fetal membrane” or “placental membrane”

  • It appears that amnion is being used for an earlier developmental stage (prior to development of the placenta proper). In this case, should introduce a new term: “amniotic membrane”
  • It appears that chorion membrane is being used as a more general term. In this case, would suggest:
    • Change “chorion membrane” to “chorion”
    • Introduce a new term: “chorionic membrane”

• [ ] Chorionic plate: We propose to move “chorionic plate” to be directly a “part-of” the placenta, and organize chorionic villus under it. The terms primary, secondary, and tertiary villus are used in a developmental sense. For the established placenta, would be better to use the terms primary, secondary, and tertiary stem villus.

  

@emquardokus, do you think that addressing these four points would create a more human representation of the placenta?

[cmungall]

Thanks for the detailed clear write up!

Can I clarify what you mean by this:

Substitute 'placental labyrinth blood vessel' for placental arteries and add new terms

I don't think anything needs substituting; the current structure is:

the labyrinth term inherits a taxon constraint that says this is not in human, so the human-view file for uberon should exclude this.

however, our hierarchy is definitely too shallow here and we can add the terms you requested

I will get to the other items later...

[aleixpuigb]

Thank you for your feedback, @cmungall!

Can I clarify what you mean by this:

Substitute 'placental labyrinth blood vessel' for placental arteries and add new terms

I don't think anything needs substituting

In this ticket I have broken down the requests from experts to reflect the human placenta in uberon (https://docs.google.com/presentation/d/1HXW6nB2qzovSL6HXcvlBkiVeezvp01vn/edit#slide=id.p9). However, what we need to do now is refine the different actions in order to harmonise the current version with a more human representation of placenta.

Yes, I agree that in this case there is no need of substituting the placental labyrinth blood vessel, I will modify the action to reflect it.

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This issue has not seen any activity in the past 6 months; it will be closed automatically one year from now if no action is taken.

[github-actions[bot]]

This issue has not seen any activity in the past 6 months; it will be closed automatically one year from now if no action is taken.