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obophenotype / uberon

An ontology of gross anatomy covering metazoa. Works in concert with https://github.com/obophenotype/cell-ontology
http://obophenotype.github.io/uberon/
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NTRs in tendon terms #3212

Open jlzamanian opened 9 months ago

jlzamanian commented 9 months ago

Comment: A tendon cell atlas group is creating single cell atlases for multiple tendons (calcaneal tendon (Achilles) UBERON:0003701, tendon of semitendinosus/hamstring tendon UBERON:8480009, tendon of quadriceps femoris UBERON:0014848, tendon of supraspinatus NTR, tendon of gluteus medius NTR, tendon of long head of the biceps brachii NTR. I've created NTRs for 3 tendons not currently present in uberon.

They additionally would like terms for the tendon microanatomy they are dissecting. The 2 microanatomical structures are both in the myotendinous junction unit - the enthesis and the myotendinous junction.

enthesis UBERON:0035845 is already present as a general term under both musculoskeletal system UBERON:0002204 and connective tissue UBERON:0002384. Myotendinous junction (MTJ) does not have a term. I did tentatively make a ntr ticket for MTJ specifically for the tendon of the semitendinosus NTR, but didn't follow through because the researchers didn't confirm with me.

They are now requesting we terms for:

myotendinous junction of the semitendinosus tendon old NTR myotendinous junction of the Achilles/calcaneal tendon enthesis of supraspinatus tendon enthesis of the Achilles/calcineal tendon enthesis of the gluteus medius tendon

Preferred term label 1: myotendinous junction

Synonyms 1 MTJ

Definition (free text, please give PubMed ID) 1 The MTJ is a specialized anatomical region that connects skeletal muscle to tendon. PMID: 23738275

The MTJ has a distinctive form with the muscle membrane having many infolds which the collagen fibrils from the tendon join with. This unique structure creates an increased area for force transmission between muscle and tendon resulting in better force dispersal and less focal stress. Physiopedia

Parent term 1 (use https://www.ebi.ac.uk/ols/ontologies/uberon)

The MTJ is part of both tendon and muscle so it should be under both.

tendon UBERON:0000043 part of muscle head UBERON:0011906 part of or maybe skeletal muscle organ, vertebrate UBERON:0014892 part of

Your nano-attribution (ORCID) 000-0003-1256-7496

Question Is it appropriate to request additional terms for association of enthesis and MtJ for specific tendon/muscle pairs?

jlzamanian commented 9 months ago

Preferred term label 2: myotendinous junction of the calcaneal tendon

Synonyms 2:

myotendinous junction of the Achilles tendon MTJ of the Achilles tendon MTJ of the calcaneal tendon

Definition (free text, please give PubMed ID) 2: The MTJ is a specialized anatomical region that connects skeletal muscle to tendon. PMID: 23738275

The MTJ has a distinctive form with the muscle membrane having many infolds which the collagen fibrils from the tendon join with. This unique structure creates an increased area for force transmission between muscle and tendon resulting in better force dispersal and less focal stress. Physiopedia

Parent term 2: (use https://www.ebi.ac.uk/ols/ontologies/uberon)

The MTJ is part of both tendon and muscle so it should be associated with both.

calcaneal tendon UBERON:0003701 part of triceps surae UBERON:0001665 part of

myotendinous junction NTR #3212 (this one) subclass of

jlzamanian commented 9 months ago

Preferred term label 3: myotendinous junction of the semitendinosus tendon

See updates to NTR#2649

jlzamanian commented 9 months ago

Preferred term label 4: enthesis of supraspinatus tendon

Synonyms 4: none

Parent term 4: (use https://www.ebi.ac.uk/ols/ontologies/uberon)

enthesis UBERON:0035845 subclass of attached to some supraspinatus tendon NTR

Definition 4:

Same as for enthesis

jlzamanian commented 9 months ago

Preferred term label 4: enthesis of gluteus medius tendon

Synonyms 4: none

Parent term 4: (use https://www.ebi.ac.uk/ols/ontologies/uberon)

enthesis UBERON:0035845 subclass of attached to some gluteus medius tendon NTR

Definition 4:

Same as for enthesis

jlzamanian commented 9 months ago

Preferred term label 4: enthesis of calcaneal tendon

Synonyms 4: enthesis of Achilles tendon

Parent term 4: (use https://www.ebi.ac.uk/ols/ontologies/uberon)

enthesis UBERON:0035845 subclass of attached to some calcaneal tendon UBERON:0003701

Definition 4:

Same as for enthesis

jlzamanian commented 6 months ago

@emquardokus @uberon Who should I be following up with in regards to the tendon terms here and in the 4 related tendon tickets.

github-actions[bot] commented 2 weeks ago

This issue has not seen any activity in the past 6 months; it will be closed automatically one year from now if no action is taken.