[NTR] New Term Request: sensory corpuscle

[lubianat]

Preferred term label:

sensory corpuscle

Synonyms COEC, COECs, cutaneous end-organ complex

Definition (free text, please give PubMed ID) A mechanosensory complex in the terminal end of some nerves that forms a corpuscle. It comprises one or more neuronal terminations and associated non-neuronal cells. PMID:35356056

Parent term (use https://www.ebi.ac.uk/ols/ontologies/uberon) mechanoreceptor structure UBERON ID: UBERON:0012449

Your nano-attribution (ORCID) https://orcid.org/0000-0003-2473-2313

Link back to Wikidata item https://www.wikidata.org/wiki/Q126363978

Relates to:

• https://github.com/obophenotype/cell-ontology/issues/2386

[lubianat]

@aleixpuigb @anitacaron I am not sure who is shepherding the issues in UBERON; I don't really have an ID range in Uberon, so I think I cannot open a PR

[aleixpuigb]

Hi @lubianat I can add this term for you. Would you like an ID range?

[lubianat]

Hi, @aleixpuigb thanks!! Having an ID range would be great; I'd be happy to make a PR. If it is any easier to just add the term, well, that works too.

Cheers!

[aleixpuigb]

I have created a PR to give you an ID range. Let me know if you would like me to create the term, or review it once you create the PR.

[lubianat]

Of note, there is an important mismatch here between UBERON and FMA.

FMA has two distinct classes, one for the neuronal part other for the multicellular structure.

For example, they split:

• Nerve ending within Pacinian corpuscle (http://purl.obolibrary.org/obo/FMA_83996)

From

• Pacinian corpuscle (http://purl.obolibrary.org/obo/FMA_83604)

In UBERON they are all merged under "nerve ending", which is a multi cell part structure.

This looks like it requires some additional modeling on the UBERON side of things. It looks like a mid-size restructuring, affecting a few dozen terms.

In the end it can be reduced to the question whether a nerve ending is just the neuronal part or if it includes the associated glia/epineurial/perineurial cells.

The definition of nerve ending on UBERON is pulled from MeSH:

Specialized terminations of peripheral neurons. Nerve endings include NEUROEFFECTOR JUNCTION(s) by which neurons activate target organs and sensory receptors (see RECEPTORS, SENSORY) which transduce information from the various sensory modalities and send it centrally in the nervous system. Presynaptic nerve endings are PRESYNAPTIC TERMINALS.

The definition of nerve in UBERON seems to refer just to the axons:

An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures.

Not sure how to proceed. Tagging @cmungall who might have experience with these sort of issues

(also maybe this should be moved to a new ticket? what do you thing @aleixpuigb ?)

[aleixpuigb]

I think the main problem is that 'sensory receptor' is_a 'nerve ending'. There can be sensory receptors that are free nerve endings, but in many cases (e.g. the Pacinian corpucle) it also involves other cells. The current EquivalentTo is: We could explore changing it, perhaps: 'anatomical structure' and ('has part' some 'nerve ending') and ('capable of' some 'detection of stimulus') I am not convinced that we need a nerve ending for each sensory cluster.

I would address this problem and some related in a different issue, and keep this ticket for the addition of 'sensory corpuscle'.

[lubianat]

From the PR

The definition of multi cell part structure is:

A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part.

In sensory corpuscles there are some complete cells. I'm not aware if there is a term that comprises parts of cells and complete cells, but I will have a look.

So apparently, the capsule of the Pacinian corpuscle is excluded from the term for Pacinian corpuscle .