how should the relationship between a lymph node and the tissues they drain be represented?

[cmungall]

Related to

• 3221

we have:

id: UBERON:8480056
name: left supraclavicular lymph node
def: "Supraclavicular lymph node located on the left side of a entire appendicular skeleton. The left supraclavicular lymph node drains the kidney, cervix, testis, and pancreas into the thoracic duct." [PMID:31335020]
is_a: UBERON:0035279 ! supraclavicular lymph node

[Term]
id: UBERON:8480057
name: right supraclavicular lymph node
def: "Supraclavicular lymph node located on the right side of a entire appendicular skeleton. The right supraclavicular lymph node drains the breast, lung and upper esophagus into the right lymphatic duct." [PMID:31335020]
is_a: UBERON:0035279 ! supraclavicular lymph node

aside: these need logical defs following the laterality patterns

The textual gloss is biologically correct, but the drains relations we decided on connect a vessel to the drained tissue/organ.

See

• https://github.com/oborel/obo-relations/issues/699

So following this schema we might have something like

left supraclavicular lymph node CONTINUOUS_WITH left supraclavicular lymphatic vessel [new term] VESSEL_DRAINS_LYMPH_FROM [new relation] lung etc

We would need a new relation here, as it's not blood that is drained, and it doesn't make sense to use the generic drains for lymph and the specific ones for blood

[cmungall]

FWIW FMA has a direct connection on the node, eg

FMA:9579    Perineum    <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:5036    Superficial inguinal lymph node
FMA:9600    Prostate    <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:229179  Right external iliac lymphatic chain
FMA:9600    Prostate    <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:229181  Left external iliac lymphatic chain
FMA:9600    Prostate    <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:234280  Sacral lymphatic chain
FMA:9600    Prostate    <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:84594   Prostatic lymphatic tree
FMA:9601    Breast  <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:236343  Lymphatic tree of breast
FMA:9601    Breast  <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:66137   Subclavian lymphatic tree
FMA:9603    Thyroid gland   <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:229074  Anterior mediastinal lymphatic chain
FMA:9603    Thyroid gland   <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:61235   Thyroid lymph node
FMA:9603    Thyroid gland   <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:75631   Brachiocephalic lymphatic chain
FMA:9607    Thymus  <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:229074  Anterior mediastinal lymphatic chain
FMA:9607    Thymus  <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:5933    Right parasternal lymph node
FMA:9607    Thymus  <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:5934    Left parasternal lymph node
FMA:9607    Thymus  <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:5951    Right tracheobronchial lymph node
FMA:9607    Thymus  <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:5952    Left tracheobronchial lymph node
FMA:9607    Thymus  <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:75631   Brachiocephalic lymphatic chain
FMA:9610    Palatine tonsil <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:223860  Superior lateral deep cervical lymphatic chain
FMA:9663    Forearm <http://purl.org/sig/ont/fma/lymphatic_drainage>    lymphatic drainage  FMA:235642  Superficial lymphatic tree of forearm
F