Open matentzn opened 5 months ago
Related issue: Map APO modifiers to PATO -- issue #927
Hi @matentzn @rays22 we have completed a first pass of splitting the APO terms into trait and process. we have done a first pass to assign process terms from GO. please take a look and let us know what you think.
APO_ID | APO term | trait? | GO_ID | GO_term_name | type of synonym |
---|---|---|---|---|---|
APO:0000193 | resistance to enzymatic treatment | trait | |||
APO:0000050 | cellular morphology | trait | |||
APO:0000051 | cell shape | trait | |||
APO:0000052 | cell size | trait | |||
APO:0000053 | cell wall morphology | trait | |||
APO:0000054 | cytoskeleton morphology | trait | |||
APO:0000055 | mitochondrial morphology | trait | |||
APO:0000056 | bud neck morphology | trait | |||
APO:0000057 | nuclear morphology | trait | |||
APO:0000058 | peroxisomal morphology | trait | |||
APO:0000059 | vacuolar morphology | trait | |||
APO:0000060 | colony appearance | trait | |||
APO:0000061 | colony color | trait | |||
APO:0000062 | colony shape | trait | |||
APO:0000063 | colony size | trait | |||
APO:0000064 | liquid culture appearance | trait | |||
APO:0000089 | budding index | trait | |||
APO:0000118 | nuclear position | trait | |||
APO:0000119 | size of nucleus | trait | |||
APO:0000120 | actin cytoskeleton morphology | trait | |||
APO:0000144 | telomere length | trait | |||
APO:0000197 | colony sectoring | trait | |||
APO:0000200 | budding pattern | trait | |||
APO:0000212 | bud morphology | trait | |||
APO:0000213 | spindle morphology | trait | |||
APO:0000214 | position of spindle pole body | trait | |||
APO:0000223 | mating projection morphology | trait | |||
APO:0000226 | subcellular morphology | trait | |||
APO:0000243 | Golgi morphology | trait | |||
APO:0000270 | endoplasmic reticulum morphology | trait | |||
APO:0000273 | nucleolar morphology | trait | |||
APO:0000335 | size of nucleolus | trait | |||
APO:0000025 | axial budding pattern | trait | |||
APO:0000026 | bipolar budding pattern | trait | |||
APO:0000044 | sporulation efficiency | trait | |||
APO:0000111 | viability | trait | |||
APO:0000336 | aneuploidy | trait | |||
APO:0000337 | polyploidy | trait | |||
APO:0000048 | virulence | trait | |||
APO:0000216 | fitness | trait | |||
APO:0000218 | redox state | trait | |||
APO:0000297 | mitochondrial distribution | trait | |||
APO:0000298 | peroxisomal distribution | trait | |||
APO:0000299 | vacuolar distribution | trait | |||
APO:0000300 | endoplasmic reticulum distribution | trait | |||
APO:0000301 | Golgi distribution | trait | |||
APO:0000302 | vesicle distribution | trait | |||
APO:0000327 | hydrostatic pressure resistance | trait | |||
APO:0000034 | mating efficiency | trait | |||
APO:0000104 | mitochondrial rho mutation frequency | trait | |||
APO:0000110 | competitive fitness | trait | |||
APO:0000147 | heat sensitivity | trait | |||
APO:0000148 | cold sensitivity | trait | |||
APO:0000154 | petite-negative | trait | |||
APO:0000194 | ionizing radiation resistance | trait | |||
APO:0000195 | gamma ray resistance | trait | |||
APO:0000198 | mutation frequency | trait | |||
APO:0000315 | plasma membrane morphology | trait | |||
APO:0000326 | desiccation resistance | trait | |||
APO:0000241 | freeze-thaw resistance | trait | |||
APO:0000242 | lipid particle morphology | trait | |||
APO:0000303 | endomembrane system morphology | trait | |||
APO:0000316 | chronological lifespan | trait | |||
APO:0000317 | replicative lifespan | trait | |||
APO:0000307 | anaerobic growth | trait | |||
APO:0000308 | fermentative growth | trait | |||
APO:0000309 | respiratory growth | trait | |||
APO:0000095 | chemical compound accumulation | trait | |||
APO:0000109 | survival rate in stationary phase | trait | |||
APO:0000141 | critical cell size at START (G1 cellsize checkpoint) | trait | |||
APO:0000209 | protein/peptide distribution | trait | |||
APO:0000215 | toxin resistance | trait | |||
APO:0000030 | lifespan | trait | |||
APO:0000149 | protein/peptide accumulation | trait | |||
APO:0000224 | RNA accumulation | trait | |||
APO:0000274 | prion state | trait | |||
APO:0000201 | acid pH resistance | trait | |||
APO:0000202 | alkaline pH resistance | trait | |||
APO:0000203 | hypoosmotic stress resistance | trait | |||
APO:0000204 | hyperosmotic stress resistance | trait | |||
APO:0000205 | ionic stress resistance | trait | |||
APO:0000080 | stress resistance | trait | |||
APO:0000081 | killer toxin resistance | trait | |||
APO:0000082 | osmotic stress resistance | trait | |||
APO:0000083 | oxidative stress resistance | trait | |||
APO:0000084 | radiation resistance | trait | |||
APO:0000085 | UV resistance | trait | |||
APO:0000086 | X ray resistance | trait | |||
APO:0000032 | resistance to chemicals | trait | |||
APO:0000090 | metal resistance | trait | |||
APO:0000091 | starvation resistance | trait | |||
APO:0000092 | temperature sensitive growth | trait | |||
APO:0000093 | thermotolerance | trait | |||
APO:0000333 | acquired thermotolerance | trait | |||
APO:0000334 | innate thermotolerance | trait | |||
APO:0000199 | chitin deposition | trait | |||
APO:0000106 | vegetative growth | trait | |||
APO:0000310 | growth in exponential phase | trait | |||
APO:0000102 | respiratory metabolism | GO:0045333 | cellular respiration | ||
APO:0000101 | fermentative metabolism | GO:0006113 | fermentation | broad | |
APO:0000022 | protein activity | GO:0003824 | catalytic activity | narrow | |
APO:0000024 | budding | GO:0007114 | cell budding | ||
APO:0000027 | filamentous growth | GO:0030447 | filamentous growth | ||
APO:0000028 | invasive growth | GO:0036267 | invasive filamentous growth | ||
APO:0000029 | pseudohyphal growth | GO:0007124 | pseudohyphal growth | ||
APO:0000032 | mating response | GO:0019236 | response to pheromone | broad | |
APO:0000033 | cell fusion | GO:0140253 | cell-cell fusion | ||
APO:0000035 | nuclear fusion during mating | GO:0048288 | nuclear membrane fusion involved in karyogamy | ||
APO:0000036 | pheromone production | GO:0042811 | pheromone biosynthetic process | ||
APO:0000037 | pheromone sensitivity | GO:0019236 | response to pheromone | broad | |
APO:0000038 | shmoo formation | GO:0031382 | mating projection formation | ||
APO:0000039 | meiosis | GO:0051321 | meiotic cell cycle | ||
APO:0000040 | meiotic recombination | GO:0007131 | reciprocal meiotic recombination | ||
APO:0000041 | sporulation | GO:0043934 | sporulation | ||
APO:0000042 | spore germination | GO:0009847 | spore germination | ||
APO:0000043 | spore wall formation | GO:0042244 | spore wall assembly | ||
APO:0000046 | silencing | GO:0031507 | heterochromatin formation | ||
APO:0000047 | transposable element transposition | GO:0006313 | DNA transposition | ||
APO:0000065 | flocculation | GO:0000128 | flocculation | ||
APO:0000071 | cytokinesis | GO:0000910 | cytokinesis | ||
APO:0000072 | mitotic cell cycle | GO:0000278 | mitotic cell cycle | ||
APO:0000073 | intracellular transport | GO:0046907 | intracellular transport | ||
APO:0000074 | autophagy | GO:0006914 | autophagy | ||
APO:0000075 | endocytosis | GO:0006897 | endocytosis | ||
APO:0000076 | mitochondrial transport | GO:0006839 | mitochondrial transport | ||
APO:0000077 | nuclear transport | GO:0051169 | nuclear transport | ||
APO:0000078 | protein secretion | GO:0009306 | protein secretion | ||
APO:0000079 | vacuolar transport | GO:0007034 | vacuolar transport | ||
APO:0000096 | nutrient utilization | GO:0031667 | response to nutrient levels | ||
APO:0000098 | utilization of carbon source | GO:0015976 | carbon utilization | ||
APO:0000099 | utilization of nitrogen source | GO:0019740 | nitrogen utilization | ||
APO:0000100 | nutrient uptake | GO:0098739 | import across plasma membrane | broad | |
APO:0000105 | mitochondrial genome maintenance | GO:0000002 | mitochondrial genome maintenance | ||
APO:0000123 | recovery from pheromone-induced cell cycle arrest | GO:0000321 | re-entry into mitotic cell cycle after pheromone arrest | ||
APO:0000124 | pheromone-induced cell cycle arrest | GO:0000751 | mitotic cell cycle G1 arrest in response to pheromone | ||
APO:0000125 | utilization of phosphorus source | GO:0006794 | phosphorus utilization | ||
APO:0000126 | nuclear import | GO:0051170 | import into nucleus | ||
APO:0000127 | nuclear export | GO:0051168 | nuclear export | ||
APO:0000128 | peroxisomal transport | GO:0043574 | peroxisomal transport | ||
APO:0000129 | protein transport | GO:0006886 | intracellular protein transport | ||
APO:0000130 | small molecule transport | GO:0006810 | transport | broad | |
APO:0000131 | protein/peptide modification | GO:0036211 | protein modification process | ||
APO:0000132 | RNA localization | GO:0006403 | RNA localization | ||
APO:0000143 | chromosome/plasmid maintenance | GO:0051276 | chromosome organization | related | |
APO:0000145 | oxidative phosphorylation | GO:0006119 | oxidative phosphorylation | ||
APO:0000155 | apoptosis | GO:0006915 | apoptotic process | ||
APO:0000157 | utilization of iron source | GO:0031667 | response to nutrient levels | broad | |
APO:0000159 | biofilm formation | GO:0042710 | biofilm formation | ||
APO:0000196 | mating type switching | GO:0007533 | mating type switching | ||
APO:0000208 | chromosome segregation | GO:0007059 | chromosome segregation | ||
APO:0000219 | utilization of sulfur source | GO:0006791 | sulfur utilization | ||
APO:0000220 | necrotic cell death | GO:0097300 | programmed necrotic cell death | ||
APO:0000221 | septum formation | GO:0000921 | septin ring assembly | ||
APO:0000222 | chemical compound excretion | GO:0007588 | excretion | broad | |
APO:0000225 | mitotic recombination | GO:0006312 | mitotic recombination | ||
APO:0000239 | pexophagy | GO:0000425 | pexophagy | ||
APO:0000240 | mitophagy | GO:0000423 | mitophagy | ||
APO:0000253 | cell cycle progression | GO:0007049 | cell cycle | ||
APO:0000254 | cell cycle progression in G2 phase | GO:0000085 | mitotic G2 phase | ||
APO:0000255 | cell cycle progression in G1 phase | GO:0000080 | mitotic G1 phase | ||
APO:0000256 | cell cycle passage through START | GO:0007089 | traversing start control point of mitotic cell cycle | ||
APO:0000257 | cell cycle progression through the G2/M phase transition | GO:0000086 | G2/M transition of mitotic cell cycle | ||
APO:0000258 | cell cycle progression in M phase | GO:0000087 | mitotic M phase | ||
APO:0000259 | cell cycle passage through the metaphaseanaphase transition | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | ||
APO:0000260 | cell cycle progression in anaphase | GO:0000090 | mitotic anaphase | ||
APO:0000262 | cell cycle progression in mid anaphase | GO:0000091 | mitotic anaphase A | ||
APO:0000263 | cell cycle progression in late anaphase | GO:0000092 | mitotic anaphase B | ||
APO:0000264 | cell cycle progression in metaphase | GO:0000089 | mitotic metaphase | ||
APO:0000265 | cell cycle progression in telophase | GO:0000093 | mitotic telophase | ||
APO:0000266 | cell cycle progression in S phase | GO:0000084 | mitotic S phase | ||
APO:0000267 | entry into G0 (stationary phase) | GO:0070314 | G1 to G0 transition | ||
APO:0000268 | exit from G0 (stationary phase) | GO:0045023 | G0 to G1 transition | ||
APO:0000269 | cell cycle progression through the G1/S phase transition | GO:0044843 | cell cycle G1/S phase transition | ||
APO:0000271 | RNA modification | GO:0009451 | RNA modification | ||
APO:0000275 | prion inheritance | GO:0008150 | biological_process | broad | |
APO:0000276 | prion formation | GO:0008150 | biological_process | broad | |
APO:0000277 | prion loss | GO:0008150 | biological_process | broad | |
APO:0000288 | adhesion | GO:0007155 | cell adhesion | ||
APO:0000312 | cell death | GO:0008219 | cell death | ||
APO:0000338 | micronucleophagy | GO:0044804 | nucleophagy | broad | |
APO:0000339 | ribophagy | GO:0034517 | ribophagy | ||
APO:0000340 | reticulophagy | GO:0061709 | reticulophagy | ||
APO:0000341 | nucleophagy | GO:0044804 | nucleophagy | ||
APO:0000342 | late nucleophagy | GO:0044804 | nucleophagy | broad |
This separation between traits and processes is very useful for GO too @pgaudet. This distinction between organization and morphology crops up a lot. There are other terms described as traits which sit badly in GO (i.e related to telomere length and mitochondrial ditribution.
Some minor suggestions.
1. APO:0000046 silencing -> GO:0031507heterochromatin formation Silencing is broader than heterochromatin formation because Transcriptional gene silencing is the combination of heterochromatin formation and decay via surveillance See for eg https://pubmed.ncbi.nlm.nih.gov/33574613/ https://pubmed.ncbi.nlm.nih.gov/33723424/ summarized nicely:
Silencing requires the coordinated action of both the RNA surveillance and the heterochromatin machinery (I hope that we can get a more precise term to represent TGS in GO- to be discussed)
2. APO:0000096 nutrient utilization GO:0031667 response to nutrient levels Response to nutrient levels is broader (this aligns with how you describe ‘utilisation of iron source)
3. ~APO:0000221 septum formation GO:0000921 septin ring assembly GO:0000917 division septum assembly Is probably the correct term here as the septin ring and the septum are independent? (Maybe septic ring assembly in GO should move under GO:0000917 ?)~ ignore this one, obs budding yeast doesn't build a division septum!
4. APO:0000253 cell cycle progression GO:0007049 cell cycle (in the current GO organisation this is broad because it includes cell cycle events in addition to "control of progression", (although I would like this to change eventually).
5. For these, note that they should probably be related, because these terms describe 'phases' not processes (they should really be in a different ontology), and they don't describe progression. We have used these in FYPO logical defs but the qualifiers are always related to progression (i.e delay, duration etc) APO:0000254 cell cycle progression in G2 phase GO:0000085 mitotic G2 phase APO:0000255 cell cycle progression in G1 phase GO:0000080 mitotic G1 phase APO:0000258 cell cycle progression in M phase GO:0000087 mitotic M phase APO:0000260 cell cycle progression in anaphase GO:0000090 mitotic anaphase APO:0000262 cell cycle progression in mid anaphase GO:0000091 mitotic anaphase A APO:0000263 cell cycle progression in late anaphase GO:0000092 mitotic anaphase B APO:0000264 cell cycle progression in metaphase GO:0000089 mitotic metaphase APO:0000265 cell cycle progression in telophase GO:0000093 mitotic telophase APO:0000266 cell cycle progression in S phase GO:0000084 mitotic S phase
@srengel @ValWood fantastic job, this will help us get started! @rays22 can you can you turn @srengel work in conjunction with @ValWood comment into a google sheet in SSSOM format please, make it world-readable and share it here again?
I have created this spreadsheet for APO because I need to progress fast:
https://docs.google.com/spreadsheets/d/1pQ4VBAtfFOHLEdr1V5-4PtrtQsK50mLMQKhJ8GRpDjY/edit#gid=0
@rays22 I have not curated anything yet in there, just FYI that you dont create a new source of truth when you get to it.
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