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ohdsi-studies / TicagrelorVsClopidogrel

OHDSI network study: Net Adverse Clinical Event between Ticagrelor and Clopidogrel in Patients with Acute Coronary Syndrome
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Add interaction term analysis for maintenance aspirin dosage #9

Closed chandryou closed 5 years ago

chandryou commented 5 years ago

Add interaction term analysis for maintenance aspirin dosage based on this paper

chandryou commented 5 years ago

In post-hoc study of PLATO trial (Mahaffey et al., Circulation 2011),

Aspirin maintenance dose was defined three ways:(1) based on all aspirin given between the start of study drugs and the primary event/censoring in patients taking aspirin for at least 5 days; (2) identical to 1 except in all patients taking aspirin at least 2 days; and (3) based on aspirin doses from day 2 to the earliest of cessation of randomized therapy or primary event/censoring. Median aspirin dose was used to describe the average maintenance dose for a patient. Definition 3 is considered the most clinically meaningful because it includes all randomized patients with aspirin maintenance doses taken concomitantly with randomized therapy; aspirin doses taken after a patient stopped randomized treatment or reached the primary end point are not included.

chandryou commented 5 years ago

https://github.com/chandryou/TicagrelorVsClopidogrel/commit/5bb4b8d6557484f8ad8c57bc9de188000411b340