weshorton
commented
8 years ago To Do
- Create normalization model
- Define test protocol
- biological replicate similarity
- assess results in context of known biology
- Test normalization model
Open weshorton opened 8 years ago
weshorton
commented
8 years ago To Do
Summary
Our new normalization procedure should recapitulate expected treatment differences with respect to clonality, abundance, and other diversity measure of TCR repertoires. In addition, biological replicates should be more similar post-normalization
Significance
Not only do we need to confirm that this normalization strategy is better than our original, we will also need to compare different iterations of this model.
To Do
Need an implementable model first in order to compare results!