Self Synapses?

[wrgr]

What's the current literature on self-synapsing neurons?

I haven't gotten a clear answer on this. I'm not talking about a circuit that goes Neuron A - Neuron B - Neuron A, but rather: Neuron A (Axon) - Neuron A (Dendrite).

Do these exist?

[jovo]

how would anybody estimate the frequency of such autapses?

On Sun, Feb 1, 2015 at 9:04 PM, William Gray notifications@github.com wrote:

What's the current literature on self-synapsing neurons?

I haven't gotten a clear answer on this. I'm not talking about a circuit that goes Neuron A - Neuron B - Neuron A, but rather: Neuron A (Axon) - Neuron A (Dendrite)

— Reply to this email directly or view it on GitHub https://github.com/Statistical-Connectomics-Sp15/intro/issues/21.

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[wrgr]

Sparse neuronal imaging methods?  We don't know yet would be a cool answer! I've heard people affirm and deny these...

On Sun, Feb 1, 2015 at 10:46 PM, joshua vogelstein notifications@github.com wrote:

how would anybody estimate the frequency of such autapses? On Sun, Feb 1, 2015 at 9:04 PM, William Gray notifications@github.com wrote:

What's the current literature on self-synapsing neurons?

I haven't gotten a clear answer on this. I'm not talking about a circuit that goes Neuron A - Neuron B - Neuron A, but rather: Neuron A (Axon) - Neuron A (Dendrite)

— Reply to this email directly or view it on GitHub https://github.com/Statistical-Connectomics-Sp15/intro/issues/21.

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Reply to this email directly or view it on GitHub: https://github.com/Statistical-Connectomics-Sp15/intro/issues/21#issuecomment-72402967

[jovo]

not sure how a sparse neural modeling method would be able to count these. can you elaborate?

On Sun, Feb 1, 2015 at 10:48 PM, William Gray notifications@github.com wrote:

Sparse neuronal imaging methods? We don't know yet would be a cool answer! I've heard people affirm and deny these...

On Sun, Feb 1, 2015 at 10:46 PM, joshua vogelstein notifications@github.com wrote:

how would anybody estimate the frequency of such autapses? On Sun, Feb 1, 2015 at 9:04 PM, William Gray notifications@github.com wrote:

What's the current literature on self-synapsing neurons?

I haven't gotten a clear answer on this. I'm not talking about a circuit that goes Neuron A - Neuron B - Neuron A, but rather: Neuron A (Axon) - Neuron A (Dendrite)

— Reply to this email directly or view it on GitHub https://github.com/Statistical-Connectomics-Sp15/intro/issues/21.

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---

Reply to this email directly or view it on GitHub:

https://github.com/Statistical-Connectomics-Sp15/intro/issues/21#issuecomment-72402967

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[adjordan]

Is there any reason for these to exist? The concept of a self-synapsing neuron doesn't make sense to me; what is the purpose?

[indigorose1]

I'm not sure how frequent these synapses are in the brain as a whole, but there are a number of regions that express self-synapsing neurons. They're generally used for stimulus-tuning purposes in sensory areas or for pattern-recognition in hippocampus (specifically the CA3 region). However, most neurons seem to have a strong self-avoidance feature during development.