search

open-connectome-classes / StatConn-Spring-2015-Info

introductory material
18 stars 4 forks source link

Brain Similarity #40

Closed imichaelnorris closed 9 years ago

imichaelnorris commented 9 years ago

How similar are the brains of different animal species when we create brain graphs? Can we analyze similar brain regions in humans and mice and compare graphs to get any sort of meaningful comparison?

SandyaS72 commented 9 years ago

I'm guessing that depends on how you define 'similarity' for graphs.... for humans and mice, for example, there's an obvious difference in size, but if you want to think about some sort of structural similarity/difference independent of number of nodes/edges, you'd have to define a way to compute that.

jovo commented 9 years ago

note that defining metrics in graph space is an important and actively researched area!

On Wednesday, February 4, 2015, SandyaS72 notifications@github.com wrote:

I'm guessing that depends on how you define 'similarity' for graphs.... for humans and mice, for example, there's an obvious difference in size, but if you want to think about some sort of structural similarity/difference independent of number of nodes/edges, you'd have to define a way to compute that.

— Reply to this email directly or view it on GitHub https://github.com/Statistical-Connectomics-Sp15/intro/issues/40#issuecomment-72918023 .

the glass is all full: half water, half air. openconnecto.me, we're hiring! https://docs.google.com/document/d/14SApYAzxF0Ddqg2ZCEwjmz3ht2TDhDmxyZI2ZP82_0U/edit?usp=sharing , jovo.me, my calendar https://www.google.com/calendar/embed?src=joshuav%40gmail.com&ctz=America/New_York

ajulian3 commented 9 years ago

I would perform an analysis by standardizing across size and functionality of both human and mice brains and linearly map the data in order to run a comparison. Specifically, if I assign functional tasks to the patients (humor me regarding the mice) I'd run a detection algorithm on the tasks and eventually run a cross validation test to analyze independence.

imichaelnorris commented 9 years ago

Thanks!

jovo commented 9 years ago

indeed! how would you define similarity formally? or distance, in case that is easier?

On Wednesday, February 4, 2015, SandyaS72 <notifications@github.com javascript:_e(%7B%7D,'cvml','notifications@github.com');> wrote:

I'm guessing that depends on how you define 'similarity' for graphs.... for humans and mice, for example, there's an obvious difference in size, but if you want to think about some sort of structural similarity/difference independent of number of nodes/edges, you'd have to define a way to compute that.

— Reply to this email directly or view it on GitHub https://github.com/Statistical-Connectomics-Sp15/intro/issues/40#issuecomment-72918023 .

the glass is all full: half water, half air. openconnecto.me, we're hiring! https://docs.google.com/document/d/14SApYAzxF0Ddqg2ZCEwjmz3ht2TDhDmxyZI2ZP82_0U/edit?usp=sharing , jovo.me, my calendar https://www.google.com/calendar/embed?src=joshuav%40gmail.com&ctz=America/New_York