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openMetaAnalysis / Hypertonic-Saline-for-Bronchiolitis

A living systematic review
http://openmetaanalysis.github.io/Hypertonic-Saline-for-Bronchiolitis/
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Summary of changes due to new publications prior to provisional acceptance #4

Open badgettrg opened 9 years ago

badgettrg commented 9 years ago

This issue merges the prior, separate issues of new trials at ClinicalTrials.gov (issue #2) and PubMed (issue #3)

ClinicalTrials.gov - 4 new trials

  1. NCT01238848 by Espelt. Inpatients. Has length of stay
  2. NCT01488448 by Silver. Inpatients. Has length of stay
  3. NCT01276821 by Khanal. Outpatients. Has symptom score
  4. NCT02045238 by Leme. Outpatients. Has hospitalization

PubMed - 2 new trials

  1. PMID 25574983 by Ojha. Inpatients. Has Length of stay and symptom score
  2. PMID 24969648 by Teunissen. Inpatients. Has Length of stay and symptom score. LOS must be converted from IQR to SD.

New forest plots are below: Compare to current at https://github.com/openMetaAnalysis/Hypertonic-Saline-for-Bronchiolitis/tree/master/forest-plots

outcome-primary

outcome-secondary - hospitalization

outcome-secondary - symptom reduction by dosing

outcome-secondary - symptom reduction by clinical site

Additional forest plot. Helps overview data, but not needed in publication. outcome-secondary - symptom reduction by clinical site and days

badgettrg commented 9 years ago

Because of the low benefit found in the newer trials, below are two meteregressions - the first may be worth adding to the review online. They suggest that the less the length of stay in the control group, the less the benefit of hypertonic saline. There is a lesser effect from year of publication.

Residual I2 for length of stay:

metaregression_los_control_mean

metaregression_los_year