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Everything to do with the Mur Ligase Project
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Data Awaiting for WYH Compounds (AZ series) #96

Open Yuhang-CADD opened 1 year ago

Yuhang-CADD commented 1 year ago

Hi OSA team,

According to our meeting last week, the AZ compounds and others sent alongside were having technical/instrumental issues in obtaining assay data. So, in case we forgot where we are and what we want in the future, here is a spreadsheet which includes the data we have (Green), the data we need/awaiting (Amber) and the data we don't need (Red) for AZ series (WYH compounds).

image Summary_of_Biological_Evaluations_of_WYH_Compounds.xlsx

Please correct me if there is anything wrong here.

Many thanks, Yuhang

Yuhang-CADD commented 1 year ago

Update

image Summary_of_Biological_Evaluations_of_WYH_Compounds.xlsx

Yuhang-CADD commented 1 year ago

According to the latest SPR and Inhibition data, we can see the chance that the AZ5595 (WYH25-1-P) and its isomer (WYH17-12-P as well as WYH9-3-P (AZcmpd4) have a multi-targeting potential once modified properly. .

Sadly, we did not manage to spot the multi-targeting potential from the amino-derivative of AZ5595 (WYH22-3-P).

Addionally, none of the structures have managed to tacle the efflux issue.

Still awaiting IC50s.