openvax / neoantigen-vaccine-pipeline

Bioinformatics pipeline for selecting patient-specific cancer neoantigen vaccines
Apache License 2.0
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Parallelize RNA processing more effectively #9

Closed julia326 closed 6 years ago

julia326 commented 6 years ago

Something like this:

0) split the initial aligned BAMs by chromosome 1) mark dups 2) split each by CIGAR string into one containing spliced reads and one not 3) run indel realigner on each chromosome's non-spliced-reads BAM 4) merge all the things