openvax / vaxrank

Ranked vaccine peptides for personalized cancer immunotherapy
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Add N-terminal methionine check to manufacturability #188

Open julia326 opened 4 years ago

julia326 commented 4 years ago

From manufacturer, for a particular variant:

"Peptide 2 and 3 ... were selected for production since peptide 1 contains an N-terminal methionine, which is prone to oxidation during synthesis, purification and storage."

julia326 commented 4 years ago

Going to add to this issue as manufacturing concerns come up that we don't already address in our code.

We should avoid C-terminal glycines: "Peptide contains a C-terminal glycine which can be prone to side reactions during resin loading."