Closed pgleeson closed 10 years ago
Closed with 51c8bec6a2298ac2a2490b495ad5da7966a3063c
Check GABA_GJ in project
@pgleeson I remember you were talking about cleaning up the neuroConstruct proj - Is this issue something that was addressed while in Paris?
Hi, I'm having a look at this, and it looks like there was a "Generic_GJ" cell mechanism created for this purpose, but the connections in the neuroConstruct project never got changed to use it. Is this still the way we want to proceed?
If so, it looks like I can update all of the gap junction connections in CElegansNeuronTables.xls to have "Generic_GJ" in the "neurotransmitter" column, then run UpdateSynapses.py to re-import all of the data from the spreadsheet into the neuroConstruct project. We could then delete all the other superfluous "whatever_GJ" cell mechanisms.
Thanks for pointing this out @rayner. These should indeed be updated in the CElegansNeuronTables.xls, but there are a few other small inconsistencies between the spreadsheet & nC that I just want to iron out & I have to update some of the other scripts too, e.g. RegenerateConnectome.py. Will test what I have & try to commit this tomorrow...
I've updated the nC project and the spreadsheet with these fixes. See https://github.com/openworm/CElegansNeuroML/commit/99eb18f9074d1b79aa14eb9b6f1fc074b7e858cd
These names have been given to the "neurotransmitter" in the XL spreadsheet for gap junctions, e.g.
AIAL ASIL GapJunction 2 Acetylcholine_GJ
However, this only means: There are 2 gap junction connections between AIAL and ASIL (and AIAL's chemical synapses' neurotransmitter is Acetylcholine)
Thankfully there is an equivalent entry for the other direction too:
ASIL AIAL GapJunction 2 Glutamate_GJ
These should only be added as one gap junction connection in the nC project between AIAL and ASIL with 2 connections.
As a first approximation all GJ connections can have the same strength, set by a new Cell Mechanism GapJunction (as opposed to each connection having a cell mechanism Acetylcholine_GJ etc.)