Add specific comorbidities to summarise

[edward-burn]

9.3.3.2 Covariates to be assessed for Objective 2
[....]
•   Comorbidities of interest (recorded any time, and in the 365- and 30-day period before index date):
o   Chronic kidney disease
o   Solid organ transplant

[ajoedicke]

Co-morbidities for FQs - from MHRA

Risk factors for tendinopathies • Age ≥60 years • Tobacco use • Concomitant use of corticosteroids • Renal impairment • Solid organ transplant

Risk factors for aortic aneurysm/dissection • Age ≥60 years • Tobacco use • Concomitant use of corticosteroids • Cardiac or renal transplant • Vascular aneurysms • Aortic valve disorder • Hypertension • Lipid disorder • Ischaemic heart disease • Cerebrovascular disease • Connective tissue disorders (Marfan’s syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome, Turner's Syndrome) • Traumatic motor vehicle accident • Chronic obstructive pulmonary disease • Congenital heart valve disease • Family history of aneurysm disease • Behcet's disease • Rheumatoid arthritis • Takayasu arteritis or giant cell arteritis • Atherosclerosis • Sjögren's syndrome • Infective endocarditis

Risk factors for lowered seizure threshold/seizures • Epilepsy • Seizures

Risk factors for QT prolongation • Age ≥60 years • Vascular aneurysms • Hypertension

Risk factors for haemolytic reactions • Glucose-6-phosphate dehydrogenase deficiency

Risk factors for exacerbation of myasthenia gravis • Myasthenia gravis

[ajoedicke]

@edward-burn

Jsons for concept sets comorbidities and comedication for Table 1 patient charaterisation are here:

https://unioxfordnexus-my.sharepoint.com/personal/orms0426_ox_ac_uk/_layouts/15/onedrive.aspx?FolderCTID=0x01200079640BB368F60B4EB884F8ABD3DC3202&id=%2Fpersonal%2Forms0426%5Fox%5Fac%5Fuk%2FDocuments%2Fmhra%20studyathon%2Ffluroquinolones%2Fcomorbidities%5FJSON

Can we please have time windows as specified in the folders: (1) conditions recorded anytime before index date (2) comedication 1 yr before index date (3) comedication within 30days before index dates (thats for all antibiotics) (4) tests (results from AB cultures/antibiograms) within 14days before and 7 days after index date

[edward-burn]

Added (@ajoedicke please open a new issue if we want to revise the list etc)