Add Rmd file with basic simulations; also update README file

[matthieu-bruneaux]

Added a Rmd file to run basic simulations:

• For now it demonstrates only very simple simulations (one fixed effect, one grouping variable, very few different parameter values) and only two analysis methods are compared (coxph and coxme).
• However, all the basic building blocks for the simulation approach are here so we can easily add complexity as we progress in the project: more experimental designs, more parameter values, more modelling approaches to compare (including Bayesian).

Updated the README.Rmd with:

• a "Targeted audience" section
• some more links in the "Further reading" section

I also added a basic Makefile for use on Linuxes (but it should also work on Macs I think?), which is a convenient tool to automatically regenerate README.md from README.Rmd and can also be updated later to re-render rmarkdown files, run tests, etc as the project grows.

[padpadpadpad]

Hi Matthieu!

This looks great! Could I ask how would you use the Makefile to regenerate the README.md from README.Rmd. Essentially if i change README.Rmd does it all happen automatically or do I need to run something in the Terminal.

First time I have come across something like this but it looks neat.

Also thanks for uploading things cannot wait to have a look!