pato-ontology / pato

PATO - the Phenotype And Trait Ontology
https://pato-ontology.github.io/pato/
BSD 3-Clause "New" or "Revised" License
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Edit text definition and position in hierarchy for term 'pathogenicity' #225

Open CuzickA opened 5 years ago

CuzickA commented 5 years ago

Term IRI: http://purl.obolibrary.org/obo/PATO_0040003 Definition: The ability of a pathogen to produce an infectious disease or disorder in an another organism. [database_cross_reference: https://orcid.org/0000-0001-8941-3984]

Problem 1: circular definition

Problem 2: gene variants can also be pathogenic, aka hereditary or genetic diseases HTT gene in human TP53 gene in human And many, many more

One possible new definition: The ability to produce an disease or disorder in an organism.

Needs to be moved up in hierarchy as well to be directly under physical object property to allow for all types of entities (chemicals, genes, organisms) to have the ability to produce disease or disorder in an organism.

addiehl commented 5 years ago

Perhaps a better definition is The disposition to produce a disease or disorder in a susceptible organism.

Suggested placement under 'disposition'.

addiehl commented 5 years ago

See pathogenic disposition Term IRI: http://purl.obolibrary.org/obo/IDO_0000450 Definition: A disposition to initiate processes that result in a disorder. definition editor: Albert Goldfain, Lindsay Cowell, Alexander Diehl alternative term: pathogenicity http://www.w3.org/2000/01/rdf-schema#comment: The use of 'initiates' is intended to convey that a pathogenic disposition is realized when processes resulting in a disorder begin because of some action on the part of the bearer of the disposition. By this interpretation of 'initiates', disorder-causing entities such as glass, UV light, and toxins do not have a pathogenic disposition.; A pathogenic disposition is realized in processes that create a disorder.

CuzickA commented 5 years ago

Hi @addiehl Great to meet you at Biocuration2019 Tagging @ValWood and @KEHammond for further discussion