NTR: child terms of amount

[sbello]

For some terms in MP and HPO we need to distinguish between free/unbound, bound, and total amounts of proteins and chemicals in the EQ.

To do this we would like to add a set of terms as children of amount/increased amount/decreased amount (PATO:0000070/PATO:0000470/PATO:0001997)

• Free amount - The number of entities of this type that are part of the whole organism and not bound to some other compound or protein
• synonym - unbound amount
• Increased free amount - An amount of free entity that is relatively high
• Decreased free amount - An amount of free entity that is relatively low
• Bound amount - The number of entities of this type that are part of the whole organism and bound to some other compound or protein
• Increased bound amount - An amount of bound entity that is relatively high
• Decreased bound amount - An amount of bound entity that is relatively low
• Total amount - The number of entities of this type that are part of the whole organism including both bound and free forms
• Increased total amount - An amount of all types of an entity that is relatively high
• Decreased total amount - An amount of all types of an entity that is relatively high

Example terms:

• Abnormal circulating free T3 concentration vs abnormal circulating triiodothyronine level
• Abnormal circulating free T4 concentration vs abnormal circulating thyroxine level

Discussed on UPheno call 11/17/23

[anna-anagnostop]

Do we need to extend the proposed definitions to account for entities that are free or bound to some cell structure/organelle? An example would be "free" versus "bound" ribosomes. Free ribosomes are not attached to any other cell structure/organelle and are freely floating in the cytoplasm. Bound ribosomes are attached to the cytosolic side of the endoplasmic reticulum.