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patrickbryant1 / SpeedPPI

Rapid protein-protein interaction network creation from multiple sequence alignments with Deep Learning
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Is it possible to predict the interaction with true protein stucture #12

Closed MinjieHu closed 1 year ago

MinjieHu commented 1 year ago

Dear developer,

Thanks for this great tool!

Although Alphafold did a great job of predicting protein structure, sometimes the predicted structure could be different from the true structure. Considering a scenario, I got a protein structure from wet-lab experiment and I want to predict the potential interaction proteins. Is it possible to modify some parts of this pipeline so that it can handle such tasks?

Thanks in advance for any help!

Minjie

patrickbryant1 commented 1 year ago

Hi,

You request to bias the predictions according to some constraints. This is nothing that we provide, but you can have a look here: https://github.com/JeffSHF/ColabDock

Hope this helps!