search

paulgeeleher / pRRophetic

R package
21 stars 13 forks source link

Question about estimated IC50 #4

Open MMriran opened 4 years ago

MMriran commented 4 years ago

Hi Paul,

 Thank you for your great work on philentropy, it is really useful for us and I had a question to ask.

I had successfully in estimating the IC50 for my own data by "pRRopheticPredictand" function and I

found that estimated IC50 can be a negative value. So how can I explain the negative IC50？

Thank you for reading this issue. Looking forward to your reply. Thank you.

Best, MMriran

paulgeeleher commented 4 years ago

Hi MMriran

The reason for this is that the model was originally fit using log-transformed IC50 values. Thus, IC50s between 0 and 1 would produce negative values (e.g. log10(.5)=-.3).

Paul.

MMriran commented 4 years ago

Hi Paul

I really appreciated your kindness. Thank you again.

Best wishes! MMriran