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perishky / meffil

Efficient algorithms for analyzing DNA methylation data.
Artistic License 2.0
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DMPs vs DMRs #43

Closed neuromik closed 1 year ago

neuromik commented 2 years ago

Looks like EWAS function gives DMPs as an outcome. Is it possible to do DMR analysis? I've read in some studies that DMRs is a better way to compare methylation pattern.

Thanks!

perishky commented 2 years ago

Although meffil doesn't implement any DMR methods, DMR analyses are possible using a variety of different methods using meffil output, either EWAS summary statistics (e.g. a method we designed and implemented https://github.com/perishky/dmrff) or normalised data (e.g. https://github.com/timpeters82/DMRcate-release or https://github.com/raivokolde/seqlm).