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petermr / CEVOpen

Contentmining of Open phytochemical literature for medicinal activities
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💡Wishlist of Features/Capabilities to Consider #43

Closed EmanuelFaria closed 4 years ago

EmanuelFaria commented 4 years ago

A place to propose/debate ideas for future features (or at least get them out of our head). ;)

EmanuelFaria commented 4 years ago

Proposed: A mechanism to distinguish and lable Activities Synergistic or Antagonistic to each other, which we may then relate Essential Oils (ie. organic chemical mixtures) and/or their individual compounds to those activities.

Desired Result: A useful way to search for EOs by selecting all the the activities I want, and automatically be proposed a list of incompatible EOs that also exhibit activities I don't want.

Examples: (I imagine this as a table with two columns

  1. Clearly Antagonistic Activities: Irritant vs Anti-irritant (or other synonyms like Counter-irritant)
  2. Possibly Synergistic Activities: Dermatitigenic and Pro-inflammatory

Note that #2 would in most cases be considered a "Bad" (possibly) synergistic duo, unless, for example, you were seeking to test substances that created maximum inflammation. (I pity the poor lab animal).

Personal note: I dream of having this capability make selecting ingredients easier for me, but I can't get a grip on whether such categorization is actually possible. If one of you tells me it's impossible (or even overly impractical), at least I can get this out of my head.

EDIT: Perhaps some of this could be resolved by linking these activities to separate dictionaries for things like (In the case of the pathogenesis of Inflammation):

petermr commented 4 years ago

On Fri, Oct 25, 2019 at 6:19 PM Emanuel Faria notifications@github.com wrote:

Proposed: A mechanism to distinguish and lable Activities Synergistic or Antagonistic to each other, which we may then relate Essential Oils (ie. organic chemical mixtures) and/or their individual compounds to those activities.

I don't see any papers reporting synergism.

Desired Result: A useful way to search for EOs by selecting all the the activities I want, and automatically be proposed a list of incompatible EOs that also exhibit activities I don't want.

Examples: (I imagine this as a table with two columns

  1. Clearly Antagonistic Activities: Irritant vs Anti-irritant (or other synonyms like Counter-irritant)
  2. Possibly Synergistic Activities: Dermatitigenic and Pro-inflammatory

Note that #2 https://github.com/petermr/CEVOpen/issues/2 would in most cases be considered a "Bad" (possibly) synergistic duo, unless, for example, you were seeking to test substances that created maximum inflammation. (I pity the poor lab animal).

Personal note: I dream of having this capability make selecting ingredients easier for me, but I can't get a grip on whether such categorization is actually possible. If one of you tells me it's impossible (or even overly impractical), at least I can get this out of my head.

This is beyond the scope of the papers we have selected I suspect. We cannot get more out f the papers than they contain. This is not a wide-ranging knowledgebase

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