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petermr / CEVOpen

Contentmining of Open phytochemical literature for medicinal activities
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❓ QUESTIONS for Gita #7

Closed EmanuelFaria closed 4 years ago

EmanuelFaria commented 4 years ago

We've got questions, Gita's got answers!

EmanuelFaria commented 4 years ago

@gilienv When looking at a value of a compound derived from Gas Chromatography, can we be sure at the specific "chiral type" of the compound? To be certain does the method need to be listed as Chiral Gas Chromatography?

gilienv commented 4 years ago

Chirality cannot be derived from regular GC experiments. Most of the data we have in EssoilDB is non chiral GC.

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On 29-Aug-2019, at 04:36, Emanuel Faria notifications@github.com wrote:

@gilienv When looking at a value of a compound derived from Gas Chromatography, can we be sure at the specific "chiral type" of the compound? To be certain does the method need to be listed as Chiral Gas Chromatography?

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petermr commented 4 years ago

That's what I assumed. So how do they "know" the chirality when they report the profile. Just guess it's the commonest or only isomer?

gilienv commented 4 years ago

I meant that most profile datasets do not have chirality information.

However, it is possible “in some cases” to separate/ identify the enantiomers of a given compound. They use a special filter in the GC for this and in such cases, the Methodology section of the paper would mention that its chiral GC. Even so, we may never get enantiomers for each compound in the profile.

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On 29-Aug-2019, at 23:09, petermr notifications@github.com wrote:

That's what I assumed. So how do they "know" the chirality when they report the profile. Just guess it's the commonest or only isomer?

— You are receiving this because you were mentioned. Reply to this email directly, view it on GitHub, or mute the thread.