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pharmacome / curation

Guidelines and procedures for curation (manual and semi-automated)
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Add Allosteric modulator example #6

Open cthoyt opened 5 years ago

cthoyt commented 5 years ago

Allosteric modulators do not bind to the agonist-binding site of the receptor but instead on specific allosteric binding sites, through which they modify the effect of the agonist. For example, benzodiazepines (BZDs) bind to the BZD site on the GABAA receptor and potentiate the effect of endogenous GABA.

a(BZSs) -> complex(GABAA, a(BZSs))
complex(GABAA, a(BZSs)) -> act(endogenous ligand)
act(endogenous ligand) -> act(GABAA)
a(BZSs) -> complex(GABAA, a(BZSs))
complex(GABAA, a(BZSs)) -> complex(GABAA, a(BZSs), a(endogenous ligand))
complex(GABAA, a(BZSs), a(endogenous ligand)) -> act(GABAA)