Apply tcr-dist on amino acid sequences

Hi Ruoxing,

Thanks for your interest! I would recommend instead using the new tcrdist3 tool which is better documented and actively supported.

https://github.com/kmayerb/tcrdist3

For calculating TCRdist distances you do not need CDR3 nucleotide sequences, but you will need V gene identifiers.

Take care, Phil

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Hello,

Thanks for developing such great tools!

I am wondering if there is a way to apply tcr-dist on cdr3 amino acid sequences. Currently, the instructions say it is required "nucleotide sequences of the TCR alpha and beta chain reads". However, we got a dataset with amino acid sequences instead of nucleotide sequences and would like to try your methods.

Thanks so much for your help in advance!

Best regards, Ruoxing

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phbradley / tcr-dist

Apply tcr-dist on amino acid sequences #44