statistical method for testing degree of clustering/distance between groups of TCRs?

phbradley / tcr-dist

Software tools for the analysis of epitope-specific T cell receptor (TCR) repertoires (scroll down for the README)

MIT License

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statistical method for testing degree of clustering/distance between groups of TCRs? #45

Open dxl3742 opened 6 months ago

dxl3742 commented 6 months ago

Hi there, Great work on the package! I've been using tcrdist3 to compute pairwise distance between my tcr sequences. I want to say that one group of tcr sequences are more clustered (more close together, more similar) than another group. How best could I go about testing this? Should I go from the network and calculate say number of nodes for each group, or from the distance matrix and use PERMANOVA or something similar?