phbradley / tcr-dist

Software tools for the analysis of epitope-specific T cell receptor (TCR) repertoires (scroll down for the README)
MIT License
79 stars 36 forks source link

Change to the default distance parameters: gap_penalty_cdr3_region go… #7

Closed phbradley closed 7 years ago

phbradley commented 7 years ago

…ing from 8 to 12.

We've seen evidence that increasing this gap penalty improves performance slightly. Also, with the factor of 3 applied to amino-acid mismatches in the CDR3, the new value of 12 means that we are using the same gap penalty in the V and CDR3 regions, which makes things simpler and requires fewer overall parameters.

rerun_paper_analysis.py still uses the original parameters from the paper.