polyactis / Accucopy

Accucopy is a computational method that infers Allele-Specific Copy Number alterations from low-coverage low-purity tumor sequencing data.
https://www.yfish.org/software/Accucopy
GNU General Public License v3.0
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Suggestion on input bams? #13

Closed byemypast closed 2 years ago

byemypast commented 2 years ago

Hi @polyactis, First of all, thanks for your great work of Accucopy. It really helps a lot in my low-coverage WGS project. And I wonder which kind of bam files you would like to suggest as input bams? Such as raw bams after bwa, or sorted bams, or sorted bams with picard-MarkDuplicate procedure?

Thanks, Junyi

polyactis commented 2 years ago

It should be sorted with duplicates marked.

We have updated our documentation https://www.yfish.org/display/PUB/Accucopy#Accucopy-4.1Inputbamfiles

Thanks for the good question.

-- Prof. Yu S. Huang Director of Bioinformatics Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, CAS http://www.yfish.org/ https://sites.google.com/site/polyactis/

On Thu, Nov 11, 2021 at 4:04 PM 一朝风月 @.***> wrote:

Hi @polyactis https://github.com/polyactis, First of all, thanks for your great work of Accucopy. It really helps a lot in my low-coverage WGS project. And I wonder which kind of bam files you would like to suggest as input bams? Such as raw bams after bwa, or sorted bams, or sorted bams with picard-MarkDuplicate procedure?

Thanks, Junyi

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byemypast commented 2 years ago

Thank you for your kindly reply and your great work. Have a nice day!