polyactis / Accucopy

Accucopy is a computational method that infers Allele-Specific Copy Number alterations from low-coverage low-purity tumor sequencing data.
https://www.yfish.org/software/Accucopy
GNU General Public License v3.0
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input to pyclone-vi #21

Open jsha129 opened 1 year ago

jsha129 commented 1 year ago

Hi there, thank you for developing accucopy. it was relatively straight forward to run and fast! How do we prepare input for pyclone-vi (example: https://github.com/Roth-Lab/pyclone-vi/blob/master/examples/tracerx.tsv) from cnv.output.tsv? Specifically, how do we get major_cn and minor_cn? I think pyclone-vi only accepts integer values for both. Thanks

polyactis commented 1 year ago

Please check https://www.yfish.org/display/PUB/Accucopy#Accucopy-cnv.output.tsv

cp is the total copy number. major_allele_cp is the copy number for the major allele (=major_cn of Pyclone VI?).

We are not familiar with PYClone VI...

-- Yu S. Huang http://www.yfish.org/ https://sites.google.com/site/polyactis/

On Wed, Nov 9, 2022 at 2:07 PM Jaynish Shah @.***> wrote:

Hi there, thank you for developing accucopy. it was relatively straight forward to run and fast! How do we prepare input for pyclone-vi (example: https://github.com/Roth-Lab/pyclone-vi/blob/master/examples/tracerx.tsv) from cnv.output.tsv? Specifically, how do we get major_cn and minor_cn? I think pyclone-vi only accepts integer values for both. Thanks

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