mitochondrial translation various

[ValWood]

cox1

• [x] PPR S.c. PET309, S.p. ppr4, regulation of... (change to ISO)

• [ ] check orthology "LRPPRC (leucine-rich pentatricopeptide repeat- containing) is a PPR protein required for the stabilization and translation of both COX1 and COX3 mRNAs and thus, LRPPRC is considered to be a possible mammalian func- tional homolog of yeast Pet309 (34,35)" Mutations in human LRPPRC cause the French-Canadian-type Leigh syndrome, a neurodegenera- tive disorder caused by deficiency in COX (34).

• [x] YLR203C/MSS51 -> S.p. mss51 update product

• [x] Mam33 YIL070C -> S.p mam33 SPBC776.07 update product & GO

cox2

• [ ] PPR YMR257C (pet111) not yet found

cox3

• [ ] Pet54 YGR222W ortholog not identified
• [ ] Pet122 YER153C ortholog not identified
• [ ] Pet494 YNR045W ortholog not identified

CYTB

• [x] YPL215W - > cbp3 (SPCC4B3.17) update to translation,
  • [x] YBR120C -> cbp6 update to translation,

"Among the S. cerevisiae mitochondrial translational activators, only Pet309 and Pet111 are PPR proteins. Except for homologs of Mss51, Mam33, Cpb3 and Cpb6, no other sequence homologs of S. cere- visiae mitochondrial translational activators can be found in S. pombe. Similarly, no human homologs of the S. cere- visiae translational activators can be found by BLAST analysis."

[ValWood]

• [x] http://www.pombase.org/spombe/result/SPBC8D2.12c "TACO1, a non-PPR protein, is specifically required for translation of COX1 mRNA in mice and humans, but the mechanism is unknown (39,40). Interestingly, the sequence homologs of TACO1 exist in both S. cerevisiae and S. pombe." move down to regulation of...

[ValWood]

will have another go at this soon

https://curation.pombase.org/pombase-trac/wiki/OrthologInventoriesNoPom