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PomBase curation
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rum1 #2026

Closed Antonialock closed 4 years ago

Antonialock commented 6 years ago

regulation of protein stability rum1 regulates activity of cdc13

rum1 interacts with cdc13 which targets i for degradation via the proteasome. check paper and change annotation.

ValWood commented 6 years ago

Wait unitl tomorrow. I think I changed some of these this morning;)

Also I would not worry about this too much right now. I think GO will change the ways to annotate different types of molecular function shortly. This will be a good e.g of regulating activity by degradation. I don't think this is really regulating the activity (but it is regulating the process).

Let's discuss how we should do these consistently at the next curator meeting.

Antonialock commented 6 years ago

yeah in the paper I was doing I chose positive regulation of proteasomal ubiquitin-dependent protein catabolic process has regulation target cdc13, happens during G1

does that sound right?

I think rum1 is involved in mitotic G1 cell cycle arrest in response to nitrogen starvation it achieves this by positively regulating degradation of the cdc13 cyclin

ValWood commented 6 years ago

that sound right!

ValWood commented 5 years ago

I removed cdc2 as substrsate here because the substrate is clearly the cyclin. This menas that, although this is always CALLED a cdk inhibitor it isn't really a CDK inhibitor. It postively regulates degradation of the cyclin resulting in inhibition of CDK.

Need to find out if this is really hte best term. MAybe it's OK...