should this orthologous group split? bit2/bit61?

ValWood commented 6 years ago

http://pombase-dev.bioinformatics.nz/gene/SPAC6B12.03c

@Antonialock ?

Antonialock commented 6 years ago

this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618247/

suggests that they are paralogs if that helps

ValWood commented 6 years ago

Well they are paralogs, but I don't know if they resolve 1:1, they might but I would not know which way

https://www.flyrnai.org/cgi-bin/DRSC_orthologs.pl?input_species=4896&output_species=0&additional_filter=None&search_fields=***&search_datasets=***&gene_list=SPAC6B12.03c

ValWood commented 6 years ago

this doesn't help either. http://www.treefam.org/family/TF314826#tabview=tab1

Need to wait, can't do anything except 2:2 right now (duplication since divergence), although I agree thus is more likely a pre divergence duplication.

Often in these cases the evolutionary pressure, (via co evolution of binding partners) makes the within-organism members seem to be more similar than the between organism members (ribosomes and histones). It is however likely that 2 copies did exist inthe common ancestor. But based on available info we can't show this....

ValWood commented 6 years ago

We would need information showing that one was in one pathway/complex and one in another pathway. It isn't possible from sequence data alone.

pombase / curation

should this orthologous group split? bit2/bit61? #2154