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pombase / curation

PomBase curation
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checkpoints review/model #2970

Open ValWood opened 3 years ago

ValWood commented 3 years ago

PMID:11854406 PMID:22792081. comment This interaction depends on the phosphorylation of Crb2 on the T73 and S80 residues.

Model: DSB formation induces the phosphorylation of H2A ( c -H2A) Rad26? recruits Rad3 911 is damage sensor? Rad9 recruits Cut5 Cut5(rad4) recruits Crb2-P H4K20Me2 recruits Crb2 (@Tudor domain) Rad3 phosphorylates Crb2-T73P,S80P Crb2-T73P,S80P recruits Chk1 Rad3 phosphorylates (activatory) Chk1 ->G2/M arrest

ValWood commented 3 years ago

rad3 P mrc1 s604 605 rad3 P cds1 s604 T11 mrc1-P-s604 605 recruits Cds1 mrc1 increases P of rad3 P cds1 s604 T11