pho gene curation missing

[ValWood]

Conversely, the PHO genes are hyperrepressed in cells bearing loss-of-function mutations in components of the 3′-processing/termination machinery (12, 13).

• [x] curated. A. M. Sanchez, S. Shuman, B. Schwer, RNA polymerase II CTD interactome with 3′ processing and termination factors in fission yeast and its impact on phosphate homeostasis. Proc. Natl. Acad. Sci. U.S.A. 115, E10652–E10661 (2018).
• [x] curated 13. A. M. Sanchez, A. Garg, S. Shuman, B. Schwer, Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3′ processing and transcription termination that functions via its effects on CTD phosphatase Ssu72. Nucleic Acids Res. 48, 4811–4826 (2020).

[ValWood]

Replacement of all fission yeast CTD Ser7 residues with alanine results in derepression of pho1, pho84, and tgp1 expression in phosphate-replete cells, whereas replacement of all Thr4 residues with alanine causes pho1 and pho84 hyperrepression (12).

[ValWood]

• [x] this one is done

• We hadshown that an active site mutation in the N-terminal kinase domain that abolishes IP8 synthesis results in hyperrepression of pho1 expression, while an active site mutation in the pyrophosphatase domain (that elevates IP8 levels) causes pho1 derepression in a manner that requires CPF subunits and Rhn1 (25).

• [x] this one is done

  25. A. M. Sanchez, A. Garg, S. Shuman, B. Schwer, Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3′ processing and transcription termination. Nucleic Acids Res. 47, 8452–8469 (2019).