human ortholog, various

ValWood commented 1 year ago

[x] sld3 = treslin TICRR jackhammr iteration 7 (submitted to InterPRO)
[x] Update species distribution

ValWood commented 1 year ago

[x] Reevaluate orthlog prediction for ank1 orthlog (use Willet)

ValWood commented 1 year ago

look for ACIN1

sp|Q9UKV3|ACINU_HUMAN Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2

[ ] Acinus(ACIN1) ??? SAP domain protein. The only 'unmatched SAP domain is cce1, but this is much shorter...I can't retrieve the Jackhmmr hit but I'm predicting nst1 based on location , length and composition, nd current fungal restiction....

ValWood commented 1 year ago

look for: https://www.pombase.org/gene/SPCC23B6.02c Jackhammr converged on fungi & plant A thaliana https://www.uniprot.org/uniprotkb/O81841/

ValWood commented 1 year ago

Vir1p, the Yeast Homolog of Virilizer, is Required for mRNA m6A Methylation and Meiosis MUM2 SLZ1 IME4 methyltransferase Ygl036w VIR1 jackhammer converges at 52

Top interactors SSA4. ssa1 / SPAC13G7.02c hsp SIP5. zf-C3HC4 type zinc finger

KAR4 DNA binding TF

Human WTAP. == MUM2 (candida iteration 3) Human ZC3H13 Human VIRMA Candidate mcp3 Human CBLL1 running jack. == cryophillus RBM15

https://pubmed.ncbi.nlm.nih.gov/36930734/ http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12433

ValWood commented 1 year ago

Fix ortholog https://www.pombase.org/gene/SPAC3A12.03c

and look at iec1

ValWood commented 1 year ago

KICSTOR is a complex of four proteins coded by the genes KPTN, ITFG2, C12orf66, and SZT2

ValWood commented 1 year ago

I'm pretty convince rtt109 = https://www.uniprot.org/uniprotkb/Q09472/entry ask colin (big length difference)

ValWood commented 1 year ago

human WTAP

sp|Q15007|FL2D_HUMAN Pre-mRNA-splicing regulator WTAP OS=Homo sapiens OX=9606 GN=WTAP PE=1 SV=2 MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKYTDLNSNDVTGLRESEE KLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLF FLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRI AQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLKETRQQLAQYQ QQQSQASAPSTSRTTASEPVEQSEATSKDCSRLTNGPSNGSSSRQRTSGSGFHREGNTTE DDFPSSPGNGNKSSNSSEERTGRGGSGYVNQLSAGYESVDSPTGSENSLTHQSNDTDSSH DPQEEKAVSGKGNRTVGSRHVQNGLDSSVNVQGSVL

Jackhmmr iteration 2 detects

tr|Q5AJX6|Q5AJX6_CANAL Mum2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=MUM2 PE=4 SV=1 MSSNDSADYRNKFWSSTSRQVGTSFQPLGKEESYANRYPLVRSETFPPTKDETPYSSIDS SANKYMKNTMINAPSYIPYYRKDDSFEMLQEDYNKLKGELILKNQIIKNLTDQISIMTKT DQPPTFMAPKNHYQLFQDLSKTLQEKSTELQETNQRLEAVLVANSENYDVEELSHKLVHR LTQLQQENENLLKIISFGNKTNLLIEIGLLKHEIELLKKGKDGFVL

ValWood commented 11 months ago

[x] SPBC32H8.05 is human LLPH

pombase / curation

human ortholog, various #3476