sid4/cdc11/spg1

[ValWood]

• The localization of SIN components including Spg1p to the SPB is required for cytokinesis and is dependent on Sid4p, a constitutive resident of SPBs.
• We report that Cdc11p is present constitu- tively at SPBs and that its function appears to be required for the localization of all other SIN components to SPBs with the exception of Sid4p.
• Spg1p (Schmidt et al., 1997), a small Ras-superfamily GTPase that resides at the SPB(s)
• During metaphase, it becomes activated at both SPBs (GTP-bound form), but during anaphase B, it becomes inactivated at only one pole giving rise to a poorly understood asymmetric state (Sohrmann et al., 1998).
• The Sid1p protein kinase, in a complex with Cdc14p, is then recruited to the SPB that contains Cdc7p and activated Spg1p at this time (Guertin et al., 2000).
• can say WHICH spb