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cul4/ddb1 epe1 #3635

Open ValWood opened 9 months ago

ValWood commented 9 months ago

The Cul4-Ddb1(Cdt)2 ubiqui- tin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin. Cell. 2011; 144(1):41–54. https://doi.org/10.1016/j.cell.2010.11.051 PMID: 21215368

ValWood commented 9 months ago

A JmjC domain-containing protein, S. pombe Epe1, has been identified as an anti-silencing factor at heterochromatin-euchromatin boundaries [11–14]. The Cul4-Ddb1Cdt2 ubiquitin ligase complex moderately degrades Epe1 located inside the boundaries [15, 16

ValWood commented 9 months ago

Epe1 physically interacts with the HP1 homologs Swi6 and Chp2 and localizes to heterochromatin in a largely Swi6-dependent manner [12, 15, 19, 20]

  1. Zofall M, Grewal SIS. Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochro- matic repeats. Mol Cell. 2006; 22(5):681–692. https://doi.org/10.1016/j.molcel.2006.05.010 PMID: 16762840
  2. Braun S, Garcia JF, Rowley M, Rougemaille M, Shankar S, Madhani HD. The Cul4-Ddb1(Cdt)2 ubiqui- tin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin. Cell. 2011; 144(1):41–54. https://doi.org/10.1016/j.cell.2010.11.051 PMID: 21215368
  3. Bayne EH, Bijos DA, White SA, de Lima Alves F, Rappsilber J, Allshire RC. A systematic genetic screen identifies additional factors influencing centromeric heterochromatic integrity in fission yeast. Submitted. Genome Biology. 2014; 15(10):481.
  4. Sadaie M, Kawaguchi R, Ohtani Y, Arisaka F, Tanaka K, Shirahige K, et al. Balance between distinct HP1 family proteins controls heterochromatin assembly in fission yeast. Mol Cell Biol. 2008; 28 (23):6973–6988. https://doi.org/10.1128/MCB.00791-08 PMID: 18809570
  5. Shimada A, Dohke K, Sadaie M, Shinmyozu K, Nakayama J-I, Urano T, et al. Phosphorylation of Swi6/ HP1 regulates transcriptional gene silencing at heterochromatin. Genes Dev. 2009; 23(1):18–23. https://doi.org/10.1101/gad.1708009 PMID: 19136623