Annotating drug targets (student project?)

Check if any of these are not in our list https://www.pombase.org/browse-curation/drugs-known-pombe-targets

For the time being I am going to moved the 3 curated to "misc" as there are only 3..... problem with target annotation of SPCC16C4.09: can't find feature for: staurosporine problem with target annotation of SPAC1805.17: can't find feature for: Leptomycin problem with target annotation of SPCC1753.04: can't find feature for: lithium

Perhaps they might be most useful under "experimental tools"?

List of drugs:

[x] alpha-amanitin Pol II
[x] tagetitoxin/tagetin Pol III
[x] cyclohexamide Pol I ? we have 60S ribosomal subunit inhibitor which sounds correct
[x] lovastatin competative inhibitor of HMGR. add gene hmg1
[x] pravastatin HMGR inhibitor
[x] Arborcandin C 1,3-beta-Glucan Sunthase
[x] CT2108A and B fatty acid synthase
[x] alverine citrate proteasome /lipid synthesis?
[x] amiloride sodium transporter inhibitor
[x] amphotericin sterol biosynthesis inhibitor/ create pores cause lysis
[x] ansiomycin translation inhibitor
[x] antifungal azoles sterol biosynthesis inhibitors
[x] benomyl spindle poison nda3
[x] bleomycin fungal cell wall septation and cytokinesis inhibitors
[x] brefeldin/monensin intracellular transport
[x] calcofluor White Interferes with cell wall synthesis
[x] camptothecin replication fork breakage
[x] canavanine L-arginine antimetabolite naturally occuring (alfalfa)
[x] chloramphenicol Protein synthesis inhibitor
[x] compactin ergosterol bio
[x] cyclohexamide translation inhibitor
[x] cyclosporin A cyclophilin
[x] dihydromotuporamine C proteasome/lipid synthesis?
[x] echinocandin Interfere with cell wall synthesis
[x] fenpropimorph proteasome /lipid synthesis?
[x] hydroxyurea ribonucleotide reductase, replication fork stalling
[x] hygromycin_B translation inhibitor
[x] isopropyl N-3-chlorophenyl carbamate spindle poison
[x] itraconazole "
[x] lantruculin cytoskeletal
[x] leptomycin B nuclear export receptor Crm1
[x] methyl-2-benzimidazole-carbamate reversible MT inhibitor
[x] natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane
[x] nystatin ergosterol biosynthesis;(antifungal; ergosta-5,7,22,24,(28)-tetraenol binding
[x] oxazolidinones Protein synthesis inhibitor
[x] phleomycin DNA strand breaks
[x] ricin spliceosome independent splicing? translation?
[x] sanglifehrin A cyclophilin
[x] staurosporine protein kinase inhibitor
[x] thialysine naturally occurring lysine analogue
[x] trichostatin A (TSA) histone deacetylase
[x] tunamycin inhibits N-glycosylation
[x] zaragozic acid "
[x] antimycin A electron transport chain?

Original comment by: ValWood

pombase / curation

Annotating drug targets (student project?) #89