H3-K9 methylation phenotypes

fypoadmin commented 12 years ago

abnormal histone H3-K9 trimethylation at centromere child of FYPO:0000787

and normal histone H3-K9 dimethylation at centrome

note to self PMID:21844224 spt6-1

Original comment by: ValWood

fypoadmin commented 12 years ago

abnormal histone H3-K9 trimethylation at centromere inner repeat and normal histone H3-K9 dimethylation at centrome inner repeat

abnormal histone H3-K9 trimethylation at centromere outer repeat abnormal histone H3-K9 dimethylation at centromere outer repeat

Original comment by: ValWood

fypoadmin commented 12 years ago

can we get increased and decreased for these too?

Original comment by: ValWood

fypoadmin commented 12 years ago

and increased histone H3-K9 acetylation at centromere

Original comment by: ValWood

fypoadmin commented 12 years ago

part of me thinks maybe this is a crazy degree of pre-composition, but what the hell ... the reasoner can cope

here are your terms, plus a few more for completeness:

normal metabolic process FYPO:0000859 abnormal metabolic process FYPO:0000860 normal histone methylation FYPO:0000861 normal histone H3-K9 dimethylation at centromere FYPO:0000862 normal histone H3-K9 dimethylation at centromere inner repeat FYPO:0000863 abnormal histone H3-K9 trimethylation at centromere FYPO:0000864 abnormal histone H3-K9 trimethylation at centromere inner repeat FYPO:0000865 abnormal histone H3-K9 dimethylation FYPO:0000866 abnormal histone H3-K9 dimethylation at centromere FYPO:0000867 abnormal histone H3-K9 dimethylation at centromere inner repeat FYPO:0000868 increased histone methylation FYPO:0000869 decreased histone methylation FYPO:0000870 increased histone H3-K9 methylation FYPO:0000871 decreased histone H3-K9 methylation FYPO:0000872 increased histone H3-K9 dimethylation FYPO:0000873 increased histone H3-K9 dimethylation at centromere FYPO:0000874 increased histone H3-K9 dimethylation at centromere inner repeat FYPO:0000875 decreased histone H3-K9 dimethylation FYPO:0000876 decreased histone H3-K9 dimethylation at centromere FYPO:0000877 decreased histone H3-K9 dimethylation at centromere inner repeat FYPO:0000878 increased histone H3-K9 trimethylation FYPO:0000879 increased histone H3-K9 trimethylation at centromere FYPO:0000880 increased histone H3-K9 trimethylation at centromere inner repeat FYPO:0000881 decreased histone H3-K9 trimethylation FYPO:0000882 decreased histone H3-K9 trimethylation at centromere FYPO:0000883 decreased histone H3-K9 trimethylation at centromere inner repeat FYPO:0000884 abnormal histone H3-K9 trimethylation at centromere outer repeat FYPO:0000885 abnormal histone H3-K9 dimethylation at centromere outer repeat FYPO:0000886 increased histone H3-K9 dimethylation at centromere outer repeat FYPO:0000887 decreased histone H3-K9 dimethylation at centromere outer repeat FYPO:0000888 increased histone H3-K9 trimethylation at centromere outer repeat FYPO:0000889 decreased histone H3-K9 trimethylation at centromere outer repeat FYPO:0000890 abnormal histone H3-K9 acetylation FYPO:0000891 increased histone H3-K9 acetylation FYPO:0000892 increased histone H3-K9 acetylation at centromere FYPO:0000893

Original comment by: mah11

fypoadmin commented 12 years ago

assigned_to: nobody --> gomidori
labels: --> new ontology term
status: open --> open-accepted

Original comment by: mah11

fypoadmin commented 12 years ago

It probably does seem a little crazy, but I think people will need these distiction as as they seem to be important for disecting the processes and most terms will have multiple annotations (covering >130 genes and >200 papers). the subtle difference appear to be important to figure our the silencing/heterochromatin formation/ spreading/ centromenre silencing/centromere function. We could put some of this in extensions, but difficult to access genes with similar phenotypes..... Genrally i don't think this degree of precomposition is required, and would avoid gene product specific, residue specific or chromosome region specific terms where possible....its the sheer number of annotations which will make them warranted here....

I' missing one I need, histone H3-K14 acetylation at centromere outer repeat

Original comment by: ValWood

fypoadmin commented 12 years ago

closing - term is now in curation tool

Original comment by: mah11

fypoadmin commented 12 years ago

status: open-accepted --> closed-accepted

Original comment by: mah11

pombase / fypo

H3-K9 methylation phenotypes #126