ntr: appearance of internal membrane bubbles

[fypoadmin]

ntr: appearance of intenal membrane bubbles (at shmoo tip) (I thought I had seen something similar, maybe not)

FYPO:0001013 abnormal membrane organization child of

(if you can?) PMID:19627505 summary

Original comment by: ValWood

[fypoadmin]

Would it work to use "excess plasma membrane present", or, if you can't tell what kind of membrane, just generic "excess membrane present"?

There are some existing terms for some other membranes, e.g. FYPO:0001556 'excess nuclear envelope present', FYPO:0002652 'excess intracellular endomembrane system present'.

Original comment by: mah11

[fypoadmin]

I thought there was something like it.

Yes that will do.

It is the membrane at the shmoo tip after cell fusion, that would be a type of plasma membrane?

val

Original comment by: ValWood

[fypoadmin]

Probably ... if you think no one will howl if we say it's plasma membrane, I'll use that.

Original comment by: mah11

[fypoadmin]

I looked last night for something else and saw this :

http://www.ebi.ac.uk/QuickGO/GTerm?id=GO:0070867#term=ancchart

Original comment by: ValWood

[fypoadmin]

"Plasma membrane fusion also depends on its composition. In pheromone-treated cells, the lipid bilayer at the shmoo tip is more condensed than the rest of the plasma membrane, an organization that depends on sphingolipids [128]. In particular, phosphatidylinositol 4,5-bisphosphate (PIP2) and ergosterols are enriched at the shmoo tip, and are required for Ste5 scaffold recruitment and MAPK activation [128,129]. Ergosterols are further enriched at the fusion site and deletion of enzymes involved in the late steps of ergosterol biosynthesis causes membrane fusion delays and defects [130,131], suggesting ergosterols may act as cofactors to concentrate some unknown component of the cell-fusion machinery."

Original comment by: Antonialock

[fypoadmin]

there's a GO term for this plasma membrane part ID GO:0070250 Name mating projection membrane Ontology Cellular Component Definition The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone.

Original comment by: Antonialock

[fypoadmin]

• labels: --> new ontology term
• summary: ntr: appearance of intenal membrane bubbles --> ntr: appearance of internal membrane bubbles
• status: open --> closed-accepted
• assigned_to: Midori Harris

Original comment by: mah11

[fypoadmin]

I've gone with plasma membrane for the name, and included a narrow synonym referring to the mating projection membrane term -- (a) it makes the term available more generally; and (b) if there's excess, it may not be restricted to the shmoo.

excess plasma membrane present FYPO:0003136

Original comment by: mah11

[fypoadmin]

I could not see this term ubder? FYPO:0000813 Ontology fission_yeast_phenotype Term name abnormal plasma membrane organization

Original comment by: ValWood

[fypoadmin]

added another new term: abnormal plasma membrane FYPO:0003278

and the path is now: FYPO:0003136 is_a FYPO:0003278 --> FYPO:0003278 output_of FYPO:0000813

Original comment by: mah11