PMID:21357609

[fypoadmin]

inviable after spore germination, multiple cell divisions, multiseptate elongated bottle-shaped cell decreased mitochondrial RNA level during vegetative growth increased mitochondrial RNA level during vegetative growth

And question: I annotated rpo41 to abnormal mitochondrion organization The deletion mutant shows diffuse staining when a mitochondrial dye is added. The dye enetring the mitochondrion has something to do with the membrane potential. Therefore, they think that there is a loss of mitochondrial membrane protential in the mutant. Is this term fine? Doesn't seem quite right to me, but neitherdoes loss of mitochondrial membrnae potential (since that is not exactly what they assay either).

Original comment by: Antonialock

[fypoadmin]

• status: open --> closed-accepted

Original comment by: mah11

[fypoadmin]

inviable after spore germination, multiple cell divisions, elongated multiseptate bottle-shaped cell FYPO:0003422 decreased mitochondrial RNA level FYPO:0003423 increased mitochondrial RNA level FYPO:0003424

I don't know enough about mitochondria to second-guess your annotations. It seems to me that the dye accumulating or not isn't very specific -- e.g. if the membrane was somehow structurally compromised, it would probably lose potential too, but that wouldn't be the only thing wrong.

Original comment by: mah11

[fypoadmin]

so do you think any other term would be more appropriate?

Original comment by: Antonialock

[fypoadmin]

Assuming you mean "loss of mitochondrial membrane potential", I have no reason to think it would be wrong, but I still don't know enough about mitochondria to know whether it would be better.

Original comment by: mah11

[fypoadmin]

No, I meant "abnormal mitochondrion organization"

Original comment by: Antonialock

[fypoadmin]

Actually, that doesn't change my answer ;)

Original comment by: mah11