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Fission Yeast Phenotype Ontology
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mitotic exit phenotypes PMID:7877997 #1839

Closed fypoadmin closed 9 years ago

fypoadmin commented 10 years ago

I think it is a more specific form of perforated nuclear envelope Definition A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nuclear envelope has perforations or gaps (other than nuclear pores) instead of a continuous structure.

(when does perforated become fragmented? here the nuclear envelope does appear to break down)

So, child of abnormal nuclear envelope morphology during vegetative growth

NTR: inviable cell with fragmented nuclear envelope during mitotic telophase

and inviable cell with nuclear pore aggregation during mitotic telophase child of FYPO:0003783

and a compound term inviable cell with nuclear pore aggregation and fragmented nuclear envelope during mitotic telophase

(these phenotypes comment indicate a problem with mitotic exit)

Original comment by: ValWood

fypoadmin commented 10 years ago

Another phenotype for this paper

I want to describe "arrest with condensed chromosomes, a medial septum, and a 1C DNA content per nucleus"

I got to FYPO:0003738 Term name abnormal mitotic cell cycle arrest with condensed chromosomes but this is defined

cellular process phenotype in which progression through the mitotic cell cycle is arrested when cells have condensed chromosomes, but show no other signs of having entered mitosis or M phase, under conditions where arrest does not normally occur. Synonym abnormal mitotic cell cycle arrest with condensed chromosomes during vegetative growth

This is a phenotype where mitosis does not exit properly and the chromosomes are still condensed, and cytokinesis does not occur but mitosis proceeded properly otherwise....

???? not sure

Original comment by: ValWood

fypoadmin commented 10 years ago

NTR: abnormal mitotic exit (GO:0010458)

some of the new terms will be out_put of this term

Original comment by: ValWood

fypoadmin commented 10 years ago

FYPO:0003738 is neutral with respect to septum and DNA content, i.e. it doesn't specify whether there is a septum (or, if so, where), nor whether the DNA content is 1C, 2C, or otherwise. Added for [fission-yeast-phenotype:#1697]. I think it shouldn't be a problem to add a new child that does specify 1C DNA content and a septum present. (Isn't that attributed to another paper, though?)

Original comment by: mah11

fypoadmin commented 10 years ago

righty-ho, here's what I've added - check and make sure I didn't miss any:

abnormal exit from mitosis FYPO:0003792 abnormal nuclear pore distribution FYPO:0003973 aggregated nuclear pores present in cytoplasm FYPO:0003974 fragmented nuclear envelope FYPO:0003975 inviable vegetative cell with fragmented nuclear envelope during mitotic telophase FYPO:0003976 inviable vegetative cell with nuclear pore aggregation in cytoplasm during mitotic telophase FYPO:0003977 inviable vegetative cell with fragmented nuclear envelope and nuclear pore aggregation in cytoplasm during mitotic telophase FYPO:0003978 abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell with 1C DNA content per nucleus FYPO:0003979

Original comment by: mah11
fypoadmin commented 10 years ago

Yeah, the DNA content is another paper, but should be able to use later.

I don't see the new compound terms under

fragmented nuclear envelope FYPO:0003975 (should I are are we waiting for reasoner to fill in?)

Val

Original comment by: ValWood

fypoadmin commented 10 years ago

the links to FYPO:0003975 are has_part, so they'll be visible when Kim does that bit of Canto ...

Original comment by: mah11